Anhua Wu

TL;DR: The recommendations will provide a framework and assurance for the strategy of diagnostic and therapeutic measures to reduce complications from unnecessary treatment and cost and should serve as an application for all professionals involved in the management of patients with adult diffuse glioma and also as a source of knowledge for insurance companies and other institutionsinvolved in the cost regulation of cancer care in China.

TL;DR: Glioma purity and relevant nontumor cells within microenvironment confer important clinical, genomic, and biological implications, which should be fully valued for precise classification and clinical prediction.

TL;DR: A correlation between elevated peripheral blood NLR levels and increased tumor neutrophil infiltration/decreased CD3+ T-cell infiltration is demonstrated and is of prognostic significance independent of MGMT status and is superior to PLR as a prognostic factor.

TL;DR: A local immune signature was established for GBM, which could independently identify patients with a high risk of reduced survival, indicating the relationship between prognosis and local immune response.

TL;DR: The results indicate that the five-miRNA signature is an independent risk predictor for GBM with MGMT promoter methylation and can be used to identify patients at high risk of unfavorable outcome and resistant to alkylating chemotherapy, underscoring its potential for personalized GBM management.