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Do-Hyun Nam
Researcher at Samsung Medical Center
Publications - 413
Citations - 16430
Do-Hyun Nam is an academic researcher from Samsung Medical Center. The author has contributed to research in topics: Cancer & Glioma. The author has an hindex of 58, co-authored 384 publications receiving 13148 citations. Previous affiliations of Do-Hyun Nam include Sungkyunkwan University & Sejong University.
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Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071-22072 study): a multicentre, randomised, open-label, phase 3 trial
Roger Stupp,Roger Stupp,Monika E. Hegi,Thierry Gorlia,Sara Erridge,James Perry,Yong-Kil Hong,Kenneth Aldape,Benoit Lhermitte,Torsten Pietsch,Danica Grujicic,Joachim P. Steinbach,Wolfgang Wick,Rafal Tarnawski,Do-Hyun Nam,Peter Hau,Astrid Weyerbrock,Martin J B Taphoorn,Chiung-Chyi Shen,Nalini Rao,László Thurzó,Ulrich Herrlinger,Tejpal Gupta,Rolf-Dieter Kortmann,Krystyna Adamska,Catherine McBain,Alba A. Brandes,Joerg C. Tonn,Oliver Schnell,Thomas Wiegel,Chae-Yong Kim,Louis B. Nabors,David A. Reardon,Martin J. van den Bent,Christine Hicking,Andriy Markivskyy,Martin Picard,Michael Weller +37 more
TL;DR: This multicentre, open-label, phase 3 study investigated the efficacy of cilengitide in patients from 146 study sites in 25 countries and found none of the predefined clinical subgroups showed a benefit.
Journal ArticleDOI
Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells
Eunhee Kim,Mi-Suk Kim,Dong Hun Woo,Yongjae Shin,Jihye Shin,Nakho Chang,Young-Taek Oh,Hong Sug Kim,Jingeun Rheey,Ichiro Nakano,Cheolju Lee,Kyeung Min Joo,Jeremy N. Rich,Do-Hyun Nam,Jeongwu Lee +14 more
TL;DR: It is shown that EZH2 binds to and methylates STAT3, leading to enhanced STAT3 activity by increased tyrosine phosphorylation of STAT3.
Journal ArticleDOI
SSEA-1 Is an Enrichment Marker for Tumor-Initiating Cells in Human Glioblastoma
TL;DR: It is demonstrated that stage-specific embryonic antigen 1(SSEA-1/LeX)+ GBM cells fulfill the functional criteria for TSC/TIC, since S SEA-1+ cells are highly tumorigenic in vivo, unlike SSEA- 1- cells.
Journal ArticleDOI
Development of a T1 contrast agent for magnetic resonance imaging using MnO nanoparticles.
Hyon Bin Na,Jung Hee Lee,Kwangjin An,Yong Il Park,Mihyun Park,In Su Lee,Do-Hyun Nam,Sung Tae Kim,Seung‐Hoon Kim,Sang-Wook Kim,Keun‐Ho Lim,Ki Soo Kim,Sun‐Ok Kim,Taeghwan Hyeon +13 more
TL;DR: MRI has further advanced by the development of contrast agents that enable more specific and clearer images and enlargements of detectable organs and systems, leading to a wide scope of applications of MRI not only for diagnostic radiology but also for therapeutic medicine.
Journal ArticleDOI
Clonal evolution of glioblastoma under therapy.
Jiguang Wang,Emanuela Cazzato,Erik Ladewig,Veronique Frattini,Daniel I. S. Rosenbloom,Sakellarios Zairis,Francesco Abate,Zhaoqi Liu,Oliver Elliott,Yong Jae Shin,Jin Ku Lee,In-Hee Lee,Woong-Yang Park,Marica Eoli,Andrew J. Blumberg,Anna Lasorella,Do-Hyun Nam,Do-Hyun Nam,Gaetano Finocchiaro,Antonio Iavarone,Raul Rabadan +20 more
TL;DR: In recurrent GBM with wild-type IDH1, high LTBP4 expression is associated with worse prognosis, highlighting the TGF-β pathway as a potential therapeutic target in GBM.