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Anita Hill
Researcher at St James's University Hospital
Publications - 65
Citations - 4661
Anita Hill is an academic researcher from St James's University Hospital. The author has contributed to research in topics: Eculizumab & Paroxysmal nocturnal hemoglobinuria. The author has an hindex of 23, co-authored 65 publications receiving 3876 citations. Previous affiliations of Anita Hill include National Health Service & Leeds General Infirmary.
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Journal ArticleDOI
The complement inhibitor eculizumab in paroxysmal nocturnal hemoglobinuria.
Peter Hillmen,Neal S. Young,Jörg Schubert,Robert A. Brodsky,Gérard Socié,Petra Muus,Alexander Röth,Jeff Szer,Modupe O. Elebute,Ryotaro Nakamura,Paul Browne,Antonio M. Risitano,Anita Hill,Hubert Schrezenmeier,Chieh Lin Fu,Jaroslaw P. Maciejewski,Scott A. Rollins,Christopher F. Mojcik,Russell P. Rother,Lucio Luzzatto +19 more
TL;DR: Eculizumab is an effective therapy for PNH and Clinically significant improvements were found in the quality of life, as measured by scores on the Functional Assessment of Chronic Illness Therapy-Fatigue instrument and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire.
Journal ArticleDOI
Effect of the complement inhibitor eculizumab on thromboembolism in patients with paroxysmal nocturnal hemoglobinuria.
Peter Hillmen,Petra Muus,Ulrich Dührsen,Antonio M. Risitano,Jörg Schubert,Lucio Luzzatto,Hubert Schrezenmeier,Jeff Szer,Robert A. Brodsky,Anita Hill,Gérard Socié,Monica Bessler,Scott A. Rollins,Leonard Bell,Russell P. Rother,Neal S. Young +15 more
TL;DR: Results show that eculizumab treatment reduces the risk of clinical thromboembolism in patients with PNH.
Journal ArticleDOI
Long-term treatment with eculizumab in paroxysmal nocturnal hemoglobinuria: sustained efficacy and improved survival
Richard Kelly,Anita Hill,Louise Arnold,Gemma L Brooksbank,Stephen J. Richards,Matthew J. Cullen,Lindsay Mitchell,Dena Cohen,Walter M Gregory,Peter Hillmen +9 more
TL;DR: Eculizumab dramatically alters the natural course of PNH, reducing symptoms and disease complications as well as improving survival to a similar level to that of the general population.
Journal ArticleDOI
Thrombosis in paroxysmal nocturnal hemoglobinuria
TL;DR: Mechanisms explored include platelet activation, toxicity of free hemoglobin, nitric oxide depletion, absence of other glycosylphosphatidylinositol-linked proteins such as urokinase-type plasminogen activator receptor and endothelial dysfunction and complement inhibition with eculizumab.
Journal ArticleDOI
Paroxysmal nocturnal haemoglobinuria
TL;DR: Paroxysmal nocturnal haemoglobinuria (PNH) is a clonal haematopoietic stem cell (HSC) disease that presents with haemolytic anaemia, thrombosis and smooth muscle dystonias, as well as bone marrow failure in some cases.