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Anita K. Salyers
Publications - 5
Citations - 480
Anita K. Salyers is an academic researcher. The author has contributed to research in topics: Neuropathic pain & Analgesic. The author has an hindex of 5, co-authored 5 publications receiving 447 citations.
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Journal ArticleDOI
In vitro and in vivo characterization of A-796260: a selective cannabinoid CB2 receptor agonist exhibiting analgesic activity in rodent pain models.
B B Yao,Gin C. Hsieh,Jennifer M. Frost,Y Fan,Tiffany Runyan Garrison,Anthony V. Daza,George K. Grayson,Chang Z. Zhu,Madhavi Pai,Prasant Chandran,Anita K. Salyers,Erica J. Wensink,Prisca Honore,James P. Sullivan,Michael J. Dart,Michael Meyer +15 more
TL;DR: In vitro and in vivo pharmacological properties of A‐796260, a novel CB2 agonist, are described, which shows analgesic effects are μ‐opioid receptor‐dependent.
Journal ArticleDOI
Central and peripheral sites of action for CB2 receptor mediated analgesic activity in chronic inflammatory and neuropathic pain models in rats
Gin C. Hsieh,Madhavi Pai,Prasant Chandran,Bradley A. Hooker,Chang Z. Zhu,Anita K. Salyers,Erica J. Wensink,Cenchen Zhan,William A. Carroll,Michael J. Dart,B B Yao,Prisca Honore,Michael Meyer +12 more
TL;DR: The present study elucidated the CB2 receptor expression in ‘pain relevant’ tissues and the potential sites of action of CB2 agonism in rats to elucidate the mechanisms underlying CB2‐mediated analgesic effects.
Journal ArticleDOI
Comparison of antinociceptive actions of standard analgesics in attenuating capsaicin and nerve-injury-induced mechanical hypersensitivity
Shailen K. Joshi,Gricelda Hernandez,Joseph P. Mikusa,C.Z. Zhu,C. Zhong,Anita K. Salyers,C.T. Wismer,Prasant Chandran,Michael W. Decker,Prisca Honore +9 more
TL;DR: The results provide further support to the suggestions that distinct pharmacological mechanisms underlie capsaicin-induced acute nocifensive and SMH behaviors, and certain neuronal mechanisms underlying neuropathic pain states are also contributory to capsaicIn-induced SMH.
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H4 receptor antagonism exhibits anti-nociceptive effects in inflammatory and neuropathic pain models in rats.
Gin C. Hsieh,Prasant Chandran,Anita K. Salyers,Madhavi Pai,Chang Z. Zhu,Erica J. Wensink,David G. Witte,Thomas R. Miller,Joe Mikusa,Scott J. Baker,Jill M. Wetter,Kennan C. Marsh,Arthur A. Hancock,Marlon D. Cowart,Timothy A. Esbenshade,Jorge D. Brioni,Prisca Honore +16 more
TL;DR: It is demonstrated that selective blockade of H(4) receptors in vivo produces significant anti-nociception in animal models of inflammatory and neuropathic pain.
Journal ArticleDOI
Antinociceptive effects of histamine H3 receptor antagonist in the preclinical models of pain in rats and the involvement of central noradrenergic systems.
Gin C. Hsieh,Prisca Honore,Madhavi Pai,Erica J. Wensink,Prasant Chandran,Anita K. Salyers,Jill M. Wetter,Chen Zhao,Huaqing Liu,Michael W. Decker,Timothy A. Esbenshade,Marlon D. Cowart,Jorge D. Brioni +12 more
TL;DR: The results suggest that the spinal cord is an important site of action for H(3) antagonism and the effect can be associated with activation of the noradrenergic system, and provide support that selective H( 3) antagonists may represent a class of agents for the treatment of pain disorders.