M
Madhavi Pai
Researcher at Abbott Laboratories
Publications - 23
Citations - 1629
Madhavi Pai is an academic researcher from Abbott Laboratories. The author has contributed to research in topics: Neuropathic pain & Analgesic. The author has an hindex of 16, co-authored 20 publications receiving 1518 citations.
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Journal ArticleDOI
A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat
Michael F. Jarvis,Prisca Honore,Char Chang Shieh,Mark L. Chapman,Shailen K. Joshi,Xu Feng Zhang,Michael E. Kort,William A. Carroll,Brian E. Marron,Robert N. Atkinson,James Thomas,Dong Liu,Michael J. Krambis,Yi Liu,Steve McGaraughty,Katharine L. Chu,Rosemarie Roeloffs,Chengmin Zhong,Joseph P. Mikusa,Gricelda Hernandez,Donna M. Gauvin,Carrie Wade,Chang Zhu,Madhavi Pai,Marc J. C. Scanio,Lei Shi,Irene Drizin,Robert J. Gregg,Mark A. Matulenko,Ahmed A. Hakeem,Michael L. Gross,Matthew D. Johnson,Kennan C. Marsh,P. Kay Wagoner,James P. Sullivan,Connie R. Faltynek,Douglas S. Krafte +36 more
TL;DR: A-803467 is found, a sodium channel blocker that potently blocks tetrodotoxin-resistant currents and the generation of spontaneous and electrically evoked action potentials in vitro in rat dorsal root ganglion neurons and produces significant antinociception in animal models of neuropathic and inflammatory pain.
Journal ArticleDOI
In vitro and in vivo characterization of A-796260: a selective cannabinoid CB2 receptor agonist exhibiting analgesic activity in rodent pain models.
B B Yao,Gin C. Hsieh,Jennifer M. Frost,Y Fan,Tiffany Runyan Garrison,Anthony V. Daza,George K. Grayson,Chang Z. Zhu,Madhavi Pai,Prasant Chandran,Anita K. Salyers,Erica J. Wensink,Prisca Honore,James P. Sullivan,Michael J. Dart,Michael Meyer +15 more
TL;DR: In vitro and in vivo pharmacological properties of A‐796260, a novel CB2 agonist, are described, which shows analgesic effects are μ‐opioid receptor‐dependent.
Journal ArticleDOI
Indol-3-ylcycloalkyl Ketones: Effects of N1 Substituted Indole Side Chain Variations on CB2 Cannabinoid Receptor Activity
Jennifer M. Frost,Michael J. Dart,Karin R. Tietje,Tiffany Runyan Garrison,George K. Grayson,Anthony V. Daza,Odile F. El-Kouhen,B B Yao,Gin C. Hsieh,Madhavi Pai,Chang Z. Zhu,Prasant Chandran,Michael Meyer +12 more
TL;DR: N1 aromatic side chains also afforded several high affinity CB(2) receptor agonists but were generally less potent in an in vitro CB( 2) functional assay than were nonaromatic side chain analogues.
Journal ArticleDOI
Central and peripheral sites of action for CB2 receptor mediated analgesic activity in chronic inflammatory and neuropathic pain models in rats
Gin C. Hsieh,Madhavi Pai,Prasant Chandran,Bradley A. Hooker,Chang Z. Zhu,Anita K. Salyers,Erica J. Wensink,Cenchen Zhan,William A. Carroll,Michael J. Dart,B B Yao,Prisca Honore,Michael Meyer +12 more
TL;DR: The present study elucidated the CB2 receptor expression in ‘pain relevant’ tissues and the potential sites of action of CB2 agonism in rats to elucidate the mechanisms underlying CB2‐mediated analgesic effects.
Journal ArticleDOI
Pharmacological modulation of movement-evoked pain in a rat model of osteoarthritis.
TL;DR: The results indicate that this in vivo model utilizing a movement-induced pain behavior spawned by knee joint osteoarthritis may provide a valuable tool in examining the role of potential analgesic targets in osteoartritic pain.