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Bradley A. Hooker
Researcher at AbbVie
Publications - 11
Citations - 404
Bradley A. Hooker is an academic researcher from AbbVie. The author has contributed to research in topics: Cannabinoid receptor type 2 & Receptor. The author has an hindex of 8, co-authored 9 publications receiving 370 citations.
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Journal ArticleDOI
Central and peripheral sites of action for CB2 receptor mediated analgesic activity in chronic inflammatory and neuropathic pain models in rats
Gin C. Hsieh,Madhavi Pai,Prasant Chandran,Bradley A. Hooker,Chang Z. Zhu,Anita K. Salyers,Erica J. Wensink,Cenchen Zhan,William A. Carroll,Michael J. Dart,B B Yao,Prisca Honore,Michael Meyer +12 more
TL;DR: The present study elucidated the CB2 receptor expression in ‘pain relevant’ tissues and the potential sites of action of CB2 agonism in rats to elucidate the mechanisms underlying CB2‐mediated analgesic effects.
Journal ArticleDOI
In vitro pharmacological characterization of AM1241: a protean agonist at the cannabinoid CB2 receptor?
B B Yao,S Mukherjee,Y Fan,Tiffany Runyan Garrison,Anthony V. Daza,George K. Grayson,Bradley A. Hooker,Michael J. Dart,James P. Sullivan,Michael Meyer +9 more
TL;DR: Based on its in vivo analgesic efficacy, AM1241 has been classified as a CB2‐selective agonist, however, in vitro characterization of AM 1241 in functional assays has not been reported.
Journal ArticleDOI
Characterization of a Cannabinoid CB2 Receptor-Selective Agonist, A-836339 [2,2,3,3-Tetramethyl-cyclopropanecarboxylic Acid [3-(2-Methoxy-ethyl)-4,5-dimethyl-3H-thiazol-(2Z)-ylidene]-amide], Using in Vitro Pharmacological Assays, in Vivo Pain Models, and Pharmacological Magnetic Resonance Imaging
Betty B. Yao,Gin C. Hsieh,Anthony V. Daza,Yihong Fan,George K. Grayson,Tiffany Runyan Garrison,Odile F. El Kouhen,Bradley A. Hooker,Madhavi Pai,Erica J. Wensink,Anita K. Salyers,Prasant Chandran,Chang Z. Zhu,Chengmin Zhong,Keith B. Ryther,Megan E. Gallagher,Chih-Liang Chin,Ann Tovcimak,Vincent P. Hradil,Gerard B. Fox,Michael J. Dart,Prisca Honore,Michael Meyer +22 more
TL;DR: The identification of A-836339 as a potent and selective CB2 agonist as characterized in in vitro pharmacological assays and in in vivo models of pain and central nervous system (CNS) behavior models and investigation of the role of CB2 receptor modulation for treatment of pain in preclinical animal models are reported.
Journal ArticleDOI
Pharmacological modulation of brain activity in a preclinical model of osteoarthritis.
Jaymin Upadhyay,Scott J. Baker,Rajasimhan Rajagovindan,Michelle Hart,Prasant Chandran,Bradley A. Hooker,Steven C. Cassar,Joseph P. Mikusa,Ann Tovcimak,Michael J. Wald,Shailen K. Joshi,Anthony Bannon,Jeroen K. Medema,John D. Beaver,Prisca Honore,Rajesh V. Kamath,Gerard B. Fox,Mark Day +17 more
TL;DR: An assessment of brain function may provide an objective means by which to further evaluate the pathology of an osteoarthritis state as well as measure the pharmacodynamic effects of therapies with peripheral or peripheral and central pharmacological action.
Journal ArticleDOI
Gabapentin-induced pharmacodynamic effects in the spinal nerve ligation model of neuropathic pain.
Bradley A. Hooker,G. Tobon,Scott J. Baker,C.Z. Zhu,J. Hesterman,K. Schmidt,Rajasimhan Rajagovindan,Prasant Chandran,S.K. Joshi,A.W. Bannon,J. Hoppin,John D. Beaver,G.B. Fox,M. Day,Jaymin Upadhyay +14 more
TL;DR: This investigation aimed to map gabapentin's pharmacodynamics in the rodent brain following induction of neuropathic pain in order to further understand its PD profile.