E
Erica J. Wensink
Publications - 8
Citations - 566
Erica J. Wensink is an academic researcher. The author has contributed to research in topics: Neuropathic pain & Analgesic. The author has an hindex of 8, co-authored 8 publications receiving 521 citations.
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Journal ArticleDOI
In vitro and in vivo characterization of A-796260: a selective cannabinoid CB2 receptor agonist exhibiting analgesic activity in rodent pain models.
B B Yao,Gin C. Hsieh,Jennifer M. Frost,Y Fan,Tiffany Runyan Garrison,Anthony V. Daza,George K. Grayson,Chang Z. Zhu,Madhavi Pai,Prasant Chandran,Anita K. Salyers,Erica J. Wensink,Prisca Honore,James P. Sullivan,Michael J. Dart,Michael Meyer +15 more
TL;DR: In vitro and in vivo pharmacological properties of A‐796260, a novel CB2 agonist, are described, which shows analgesic effects are μ‐opioid receptor‐dependent.
Journal ArticleDOI
Central and peripheral sites of action for CB2 receptor mediated analgesic activity in chronic inflammatory and neuropathic pain models in rats
Gin C. Hsieh,Madhavi Pai,Prasant Chandran,Bradley A. Hooker,Chang Z. Zhu,Anita K. Salyers,Erica J. Wensink,Cenchen Zhan,William A. Carroll,Michael J. Dart,B B Yao,Prisca Honore,Michael Meyer +12 more
TL;DR: The present study elucidated the CB2 receptor expression in ‘pain relevant’ tissues and the potential sites of action of CB2 agonism in rats to elucidate the mechanisms underlying CB2‐mediated analgesic effects.
Journal ArticleDOI
Characterization of a Cannabinoid CB2 Receptor-Selective Agonist, A-836339 [2,2,3,3-Tetramethyl-cyclopropanecarboxylic Acid [3-(2-Methoxy-ethyl)-4,5-dimethyl-3H-thiazol-(2Z)-ylidene]-amide], Using in Vitro Pharmacological Assays, in Vivo Pain Models, and Pharmacological Magnetic Resonance Imaging
Betty B. Yao,Gin C. Hsieh,Anthony V. Daza,Yihong Fan,George K. Grayson,Tiffany Runyan Garrison,Odile F. El Kouhen,Bradley A. Hooker,Madhavi Pai,Erica J. Wensink,Anita K. Salyers,Prasant Chandran,Chang Z. Zhu,Chengmin Zhong,Keith B. Ryther,Megan E. Gallagher,Chih-Liang Chin,Ann Tovcimak,Vincent P. Hradil,Gerard B. Fox,Michael J. Dart,Prisca Honore,Michael Meyer +22 more
TL;DR: The identification of A-836339 as a potent and selective CB2 agonist as characterized in in vitro pharmacological assays and in in vivo models of pain and central nervous system (CNS) behavior models and investigation of the role of CB2 receptor modulation for treatment of pain in preclinical animal models are reported.
Journal ArticleDOI
H4 receptor antagonism exhibits anti-nociceptive effects in inflammatory and neuropathic pain models in rats.
Gin C. Hsieh,Prasant Chandran,Anita K. Salyers,Madhavi Pai,Chang Z. Zhu,Erica J. Wensink,David G. Witte,Thomas R. Miller,Joe Mikusa,Scott J. Baker,Jill M. Wetter,Kennan C. Marsh,Arthur A. Hancock,Marlon D. Cowart,Timothy A. Esbenshade,Jorge D. Brioni,Prisca Honore +16 more
TL;DR: It is demonstrated that selective blockade of H(4) receptors in vivo produces significant anti-nociception in animal models of inflammatory and neuropathic pain.
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Comparison of mechanical allodynia and the affective component of inflammatory pain in rats
Janel M. Boyce-Rustay,Chengmin Zhong,Rebecca Kohnken,Scott J. Baker,Gricelda H. Simler,Erica J. Wensink,Michael W. Decker,Prisca Honore +7 more
TL;DR: In inflammatory pain induced by CFA injection, PEAP is more sensitive to the effects of pain relieving compounds than mechanical allodynia, and methods other than reflex based measures of pain such as affective pain models could be more predictive of efficacy/potency in the clinic.