C
Cenchen Zhan
Publications - 5
Citations - 182
Cenchen Zhan is an academic researcher. The author has contributed to research in topics: Neuropathic pain & Analgesic. The author has an hindex of 4, co-authored 4 publications receiving 161 citations.
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Journal ArticleDOI
Central and peripheral sites of action for CB2 receptor mediated analgesic activity in chronic inflammatory and neuropathic pain models in rats
Gin C. Hsieh,Madhavi Pai,Prasant Chandran,Bradley A. Hooker,Chang Z. Zhu,Anita K. Salyers,Erica J. Wensink,Cenchen Zhan,William A. Carroll,Michael J. Dart,B B Yao,Prisca Honore,Michael Meyer +12 more
TL;DR: The present study elucidated the CB2 receptor expression in ‘pain relevant’ tissues and the potential sites of action of CB2 agonism in rats to elucidate the mechanisms underlying CB2‐mediated analgesic effects.
Journal ArticleDOI
Pharmacological characterization of A-960656, a histamine H3 receptor antagonist with efficacy in animal models of osteoarthritis and neuropathic pain
Marlon D. Cowart,Gin C. Hsieh,Lawrence A. Black,Cenchen Zhan,Erica Gomez,Madhavi Pai,Marina I. Strakhova,Arlene M. Manelli,Tracy L. Carr,Jill M. Wetter,Anthony Lee,Gilbert Diaz,Tiffany Runyan Garrison,Jorge D. Brioni +13 more
TL;DR: Its potency and efficacy in animal pain models provide support to the notion that histamine H(3) receptor antagonists are effective in attenuating nociceptive processes.
Journal ArticleDOI
Substituted Indazoles as Nav1.7 Blockers for the Treatment of Pain
Jennifer M. Frost,David A. Degoey,Lei Shi,Rebecca J. Gum,Meagan M. Fricano,Greta L. Lundgaard,Odile F. El-Kouhen,Gin C. Hsieh,Torben R. Neelands,Mark A. Matulenko,Jerome F. Daanen,Madhavi Pai,Nayereh S Ghoreishi-Haack,Cenchen Zhan,Xu-Feng Zhang,Kort Michael E +15 more
TL;DR: The genetic validation for the role of the Nav1.7 voltage-gated ion channel in pain signaling pathways makes it an appealing target for the potential development of new pain drugs and the work described herein focused on a series of 3- and 4-substituted indazoles.
Journal ArticleDOI
Mechanistic Insights Into the Analgesic Efficacy of A-1264087, a Novel Neuronal Ca2+ Channel Blocker That Reduces Nociception in Rat Preclinical Pain Models
Chang Z. Zhu,Timothy A. Vortherms,Min Zhang,Jun Xu,Andrew M. Swensen,Wende Niforatos,Torben R. Neelands,Ivan Milicic,La Geisha Lewis,Chengmin Zhong,Donna M. Gauvin,Joseph P. Mikusa,Cenchen Zhan,Madhavi Pai,Victoria A. Roderwald,Katharine L. Chu,Emily E. Cole,Anton Bespalov,Searle Xenia B,Steve McGaraughty,Robert S. Bitner,Michael F. Jarvis,Anthony W. Bannon,Shailen K. Joshi,Victoria E. Scott,Chih-Hung Lee +25 more
TL;DR: The present results demonstrate that the neuronal Ca(2+) channel blocker A-1264087 exhibits broad-spectrum efficacy through engagement of nociceptive signaling pathways in preclinical pain models in the absence of effects on psychomotor and cognitive function.
Journal ArticleDOI
Discovery of (R)-(3-fluoropyrrolidin-1-yl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)quinolin-2-yl)methanone (ABBV-318) and analogs as small molecule Nav1.7/ Nav1.8 blockers for the treatment of pain.
Meena V. Patel,Hillary M. Peltier,Mark A. Matulenko,John R. Koenig,Marc J. C. Scanio,Rebecca J. Gum,Odile F. El-Kouhen,Meagan M. Fricano,Greta L. Lundgaard,Torben R. Neelands,Xu-Feng Zhang,Cenchen Zhan,Madhavi Pai,Nayereh S. Ghoreishi-Haack,Thomas J. Hudzik,Gary Gintant,R. Martin,Steve McGaraughty,Jun-Wei Xu,Daniel A.J. Bow,J. Cory Kalvass,Philip R. Kym,David A. Degoey,Michael E. Kort +23 more
TL;DR: In this article , the authors proposed two quinolines, 3-fluoropyrrolidin-1-yl(6-((5-(trifluoromethyl)pyridin)-2-yl)oxy)quinolin-2-ol)methanone (ABBV-318) and quinoline-1.7 blockers, respectively, to improve selectivity over the hERG channel.