Convergence of Probability Measures. By P. Billingsley. Chichester, Sussex, Wiley, 1968. xii, 253 p. 9 1/4“. 117s.

Convergence of Probability Measures

Social Network Analysis

The Internet has led to the creation of a digital society, where (almost) everything is connected and is accessible from anywhere. However, despite their widespread adoption, traditional IP networks are complex and very hard to manage. It is both difficult to configure the network according to predefined policies, and to reconfigure it to respond to faults, load, and changes. To make matters even more difficult, current networks are also vertically integrated: the control and data planes are bundled together. Software-defined networking (SDN) is an emerging paradigm that promises to change this state of affairs, by breaking vertical integration, separating the network's control logic from the underlying routers and switches, promoting (logical) centralization of network control, and introducing the ability to program the network. The separation of concerns, introduced between the definition of network policies, their implementation in switching hardware, and the forwarding of traffic, is key to the desired flexibility: by breaking the network control problem into tractable pieces, SDN makes it easier to create and introduce new abstractions in networking, simplifying network management and facilitating network evolution. In this paper, we present a comprehensive survey on SDN. We start by introducing the motivation for SDN, explain its main concepts and how it differs from traditional networking, its roots, and the standardization activities regarding this novel paradigm. Next, we present the key building blocks of an SDN infrastructure using a bottom-up, layered approach. We provide an in-depth analysis of the hardware infrastructure, southbound and northbound application programming interfaces (APIs), network virtualization layers, network operating systems (SDN controllers), network programming languages, and network applications. We also look at cross-layer problems such as debugging and troubleshooting. In an effort to anticipate the future evolution of this new paradigm, we discuss the main ongoing research efforts and challenges of SDN. In particular, we address the design of switches and control platforms—with a focus on aspects such as resiliency, scalability, performance, security, and dependability—as well as new opportunities for carrier transport networks and cloud providers. Last but not least, we analyze the position of SDN as a key enabler of a software-defined environment.

https://publications.uni.lu/bitstream/10993/20596/1/survey_on_SDN.pdf

Software-Defined Networking: A Comprehensive Survey

Infectious Diseases Society of America.

The structure and dynamics of multilayer networks

It is our great pleasure to welcome you to the 9th ACM Internet Measurement Conference -- IMC 2009. This year's conference continues its tradition of being the premier forum for the dissemination of research results on furthering our understanding of how to collect or analyze Internet measurements, to give insight into how the Internet behaves. We paid particular attention to uphold IMC's salient features: the explicit encouragement of publications re-appraising previous findings on new data sets (something traditionally relegated to journal publications), and the co-existence, in the program, of both full-length and short papers. Short papers are intended to convey exciting work in progress with potentially less mature results. This year, we raised the short paper size by one page to 7 pages (as opposed to 14 pages for full papers), in an attempt to relieve the difficulty authors usually face in fitting a full set of references in their short submissions.

IMC is a very selective conference. This year, however, in response to the will of the IMC steering committee and without compromising on quality, a record number of 41 papers were accepted out of 183 submissions. More precisely, 27 full papers were accepted out of 115 submissions, and 14 short papers were accepted out of 68 submissions. As a consequence, the conference has now grown, for the first time, to a full 3-day, more inclusive program.

In selecting the final program, we were assisted by 22 highly skilled technical program committee members, who put an incredible amount of time, effort and professionalism into the selection process. We are indebted to them, as well as to our external reviewers, for their help and thank them all for their dedication. The paper selection process was carried out as 4 successive phases: in phase 1, all submitted papers received 2 reviews; this phase identified 123 papers for further consideration and that received at least an additional review during the second reviewing phase. This was followed by a phase of intensive on-line discussions which resulted in 80 papers being selected for final consideration and thorough discussions during the TPC meeting that was held in Berlin, Germany in July, and which was attended by the vast majority of the program committee members.

Proceedings of the 9th ACM SIGCOMM conference on Internet measurement

Bispecific Abs hold great potential for immunotherapy of malignant diseases. Because the first components of this new drug class are now entering clinical trials, all aspects of their mode of action should be well understood. Several studies proved that CD8(+) and CD4(+) effector T cells can be successfully redirected and activated against tumor cells by bispecific Abs both in vitro and in vivo. To our knowledge, this study provides the first evidence that bispecific Abs can also redirect and activate regulatory T cells against a surface Ag, independently of their TCR specificity. After cross-linking, via a bispecific Ab, redirected regulatory T cells upregulate the activation markers CD69 and CD25, as well as regulatory T cell-associated markers, like CTLA-4 and FOXP3. The activated regulatory T cells secrete the immunosuppressive cytokine IL-10, but, in contrast to CD8(+) and CD4(+) effector T cells, almost no inflammatory cytokines. In addition, the redirected regulatory T cells are able to suppress effector functions of activated autologous CD4(+) T cells both in vitro and in vivo. Therefore, the potential risk for activation of regulatory T cells should be taken into consideration when bispecific Abs are applied for the treatment of malignant diseases. In contrast, an Ag/tissue-specific redirection of regulatory T cells with bispecific Abs holds great potential for the treatment of autoimmune diseases and graft rejection.

Retargeting of Human Regulatory T Cells by Single-Chain Bispecific Antibodies

The present invention discloses a method and system of extracting relevant information from a collection of router configuration files and using the information to populate a data model. Each section of the router configuration files is read and parsed in a pre-specified order reflecting the dependencies within a single configuration file. Customized information about the network nodes, not reflected in the router configuration files, can be input as well into the data model. Consistency checks and policy checks can then be performed against the data. The data model provides a network-wide view of the topology and configuration, which is crucial for a variety of network engineering tasks.

System and method for packet network configuration debugging and database

Dynamic scheduling on parallel machines

Genetically engineered T lymphocytes are a promising option for cancer therapy. Prior to adoptive transfer they have to be expanded in vitro to reach therapeutically sufficient numbers. So far, no universal method exists for selective in vitro expansion of engineered T lymphocytes. In order to overcome this problem and for proof of concept we incorporated a novel unique peptide sequence of ten amino acids as epitope (E-Tag) into the binding domains of two novel chimeric antigen receptors (ECARs) directed against either prostate stem cell antigen (PSCA) for the treatment of prostate cancer (PCa) or CD33 for the treatment of acute myeloide leukemia (AML). The epitope tag then was utilized for expanding ECAR engrafted T cells by triggering the modified T cells via a monoclonal antibody directed against the E-Tag (Emab). Moreover, the E-Tag served as an efficient selection epitope for immunomagnetic isolation of modified T cells to high purity. ECAR engrafted T cells were fully functional and mediated profound anti-tumor effects in the respective models of PCa or AML both in vitro and in vivo. The method can be integrated straightforward into clinical protocols to improve therapeutic efficiency of tumor treatment with CAR modified T lymphocytes.

/pdf/a-novel-ex-vivo-isolation-and-expansion-procedure-for-4rywc4adr3.pdf

Anja Feldmann

Papers

Proceedings of the 9th ACM SIGCOMM conference on Internet measurement

Retargeting of Human Regulatory T Cells by Single-Chain Bispecific Antibodies

System and method for packet network configuration debugging and database

Dynamic scheduling on parallel machines

A Novel Ex Vivo Isolation and Expansion Procedure for Chimeric Antigen Receptor Engrafted Human T Cells