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Ann B. Vernallis
Researcher at Aston University
Publications - 20
Citations - 1048
Ann B. Vernallis is an academic researcher from Aston University. The author has contributed to research in topics: Glycoprotein 130 & Leukemia inhibitory factor. The author has an hindex of 11, co-authored 20 publications receiving 904 citations.
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Journal ArticleDOI
Does nuclear tissue infected with bacteria following disc herniations lead to Modic changes in the adjacent vertebrae
Hanne B. Albert,Peter A. Lambert,Jessica Rollason,Joan Solgaard Sorensen,Tony Worthington,Mogens Bach Pedersen,Hanne Schack Nørgaard,Ann B. Vernallis,Frederik Busch,Claus Manniche,Tom S.J. Elliott +10 more
TL;DR: Findings support the theory that the occurrence of MCs Type 1 in the vertebrae adjacent to a previously herniated disc may be due to oedema surrounding an infected disc.
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Bromelain's activity and potential as an anti-cancer agent: Current evidence and perspectives.
TL;DR: It is suggested that the anti-cancer activity of bromelain consists in the direct impact on cancer cells and their micro-environment, as well as in the modulation of immune, inflammatory and haemostatic systems.
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Leukemia inhibitory factor and its receptor promote adipocyte differentiation via the mitogen-activated protein kinase cascade.
Jérôme Aubert,Sophie Dessolin,Nathalie Belmonte,Meng Li,Fergus R. McKenzie,Laurence Staccini,Phi Villageois,Brigitte Barhanin,Ann B. Vernallis,Austin Smith,Gérard Ailhaud,Christian Dani +11 more
TL;DR: The results are in favor of a model that implicates stimulation of LIF receptor in the commitment of preadipocytes to undergo terminal differentiation by controlling the early expression of C/EBPβ and C-EBPδ genes via the mitogen-activated protein kinase cascade.
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Nrf2 activation supports cell survival during hypoxia and hypoxia/reoxygenation in cardiomyoblasts; the roles of reactive oxygen and nitrogen species
Rajitha T. Kolamunne,Irundika H.K. Dias,Ann B. Vernallis,Melissa M. Grant,Helen R. Griffiths +4 more
TL;DR: The hypothesis that Nrf2 activation by reactive oxygen and nitrogen species modulates cytotoxicity during hypoxia (H) with and without reoxygenation (H/R) in H9C2 cardiomyoblasts is explored and distinctive roles for ROS and RNS during H and H/R for NRF2 induction are supported which are important for survival independently of GSH salvage.
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Proteomic analysis of the anti‐inflammatory action of minocycline
TL;DR: The observation that minocycline inhibits some, but not all, of the LPS‐induced proteomic changes shows that minocrycline specifically affects some signalling pathways and does not completely inhibit macrophage activation.