Journal ArticleDOI
Bromelain's activity and potential as an anti-cancer agent: Current evidence and perspectives.
TLDR
It is suggested that the anti-cancer activity of bromelain consists in the direct impact on cancer cells and their micro-environment, as well as in the modulation of immune, inflammatory and haemostatic systems.About:
This article is published in Cancer Letters.The article was published on 2010-04-28. It has received 176 citations till now. The article focuses on the topics: Bromelain (pharmacology).read more
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Properties and Therapeutic Application of Bromelain: A Review
TL;DR: Bromelain accounts for many therapeutic benefits like the treatment of angina pectoris, bronchitis, sinusitis, surgical trauma, and thrombophlebitis, debridement of wounds, and enhanced absorption of drugs, particularly antibiotics.
Journal ArticleDOI
Potential role of bromelain in clinical and therapeutic applications (Review)
Vidhya Rathnavelu,Noorjahan Banu Alitheen,Subramaniam Sohila,Samikannu Kanagesan,Rajendran Ramesh +4 more
TL;DR: Bromelain is widely administered for its well-recognized properties, such as its anti-inflammatory, antithrombotic and fibrinolytic affects, anticancer activity and immunomodulatory effects, in addition to being a wound healing and circulatory improvement agent.
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Bromelain Surface Modification Increases the Diffusion of Silica Nanoparticles in the Tumor Extracellular Matrix
Alessandro Parodi,Seth G. Haddix,Nima Taghipour,Shilpa Scaria,Francesca Taraballi,Armando Cevenini,Iman K. Yazdi,Claudia Corbo,Roberto Palomba,Sm Z. Khaled,Jonathan O. Martinez,Brandon S. Brown,Lucas Isenhart,Ennio Tasciotti +13 more
TL;DR: A simple method to provide mesoporous silica nanoparticles (MSN) with a proteolytic surface was developed, which increased particle uptake in endothelial, macrophage, and cancer cell lines with minimal impact on cellular viability and showed an increased ability to digest and diffuse in tumor ECM in vitro and in vivo.
Journal ArticleDOI
Current trends of tropical fruit waste utilization
Choon Yoong Cheok,Noranizan Mohd Adzahan,Russly Abdul Rahman,Nur Hanani Zainal Abedin,Norhayati Hussain,Rabiha Sulaiman,Gun Hean Chong +6 more
TL;DR: This information is intended to inspire further research ideas in areas that are still under-explored and for food processing manufacturers who would like to minimize wastes as the norm of present day industry (design) objective.
Journal ArticleDOI
Utilization of Pineapple Waste: A Review
TL;DR: A review of previous reports along with ongoing work on utilization of pineapple wastes J. Food Sci. Technol. as mentioned in this paper 6 (10-18), 2010 DOI: http://dx.doi.org/10.3126/jfstn.v6i0.8255
References
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TGFβ in Cancer
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Smoldering and polarized inflammation in the initiation and promotion of malignant disease
TL;DR: A number of clinical trials of TNF-α antagonists alone, and in combination with other therapies, are currently underway in cancer patients, and there are suggestions of activity against advanced disease in advanced ovarian and renal cell cancer.
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Tumour microenvironment: TGFβ: the molecular Jekyll and Hyde of cancer
Brian Bierie,Harold L. Moses +1 more
TL;DR: The complex nature of TGFβ signalling and crosstalk in the tumour microenvironment presents a unique challenge, and an opportunity to develop therapeutic intervention strategies for targeting cancer.
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Understanding RAGE, the receptor for advanced glycation end products
Angelika Bierhaus,Per M. Humpert,Michael Morcos,Thoralf Wendt,Triantafyllos Chavakis,Bernd Arnold,David M. Stern,Peter P. Nawroth +7 more
TL;DR: Administration of the receptor decoy, sRAGE, is likely to sequester ligands, thereby preventing their interaction with other receptors in addition to RAGE, suggesting that, just as RAGE is a multiligand receptor, its ligands are also likely to recognize several receptors in mediating their biologic effects.