P
Phi Villageois
Researcher at University of Nice Sophia Antipolis
Publications - 31
Citations - 2199
Phi Villageois is an academic researcher from University of Nice Sophia Antipolis. The author has contributed to research in topics: Adipose tissue & Stem cell. The author has an hindex of 17, co-authored 31 publications receiving 2045 citations. Previous affiliations of Phi Villageois include Centre national de la recherche scientifique & French Institute of Health and Medical Research.
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Journal ArticleDOI
Differentiation of embryonic stem cells into adipocytes in vitro
Christian Dani,Austin Smith,Sophie Dessolin,Pascale Leroy,Laurence Staccini,Phi Villageois,C. Darimont,Gérard Ailhaud +7 more
TL;DR: The differentiation of embryonic stem cells into adipocytes will provide an invaluable model for the characterisation of the role of genes expressed during the adipocyte development programme and for the identification of new adipogenic regulatory genes.
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Expression of ob Gene in Adipose Cells REGULATION BY INSULIN
Pascale Leroy,Sophie Dessolin,Phi Villageois,Byoung Chun Moon,Jeffrey M. Friedman,Gérard Ailhaud,Christian Dani +6 more
TL;DR: In this article, the effect of insulin on obese gene expression was examined in cells of the 3T3-F442A preadipocyte clonal line and the results indicated that the ob gene is expressed in mature fat cells only and support the possibility that insulin is an important regulator of ob gene expression.
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Small RNA sequencing reveals miR-642a-3p as a novel adipocyte-specific microRNA and miR-30 as a key regulator of human adipogenesis
Laure-Emmanuelle Zaragosi,Laure-Emmanuelle Zaragosi,Brigitte Wdziekonski,Brigitte Wdziekonski,Kevin Le Brigand,Kevin Le Brigand,Phi Villageois,Phi Villageois,Bernard Mari,Bernard Mari,Rainer Waldmann,Rainer Waldmann,Christian Dani,Christian Dani,Pascal Barbry,Pascal Barbry +15 more
TL;DR: The data suggest that the miR-30 family plays a central role in adipocyte development, and the down-regulation of the osteogenesis regulator RUNX2 represents a plausible mechanism by which mi R-30 miRNAs may contribute to adipogenic differentiation of adipose tissue-derived stem cells.
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Browning of White Adipose Cells by Intermediate Metabolites:An Adaptive Mechanism to Alleviate Redox Pressure
Audrey Carrière,Yannick Jeanson,Sandra Berger-Müller,Mireille André,Vanessa Chenouard,Emmanuelle Arnaud,Corinne Barreau,Romy Walther,Anne Galinier,Brigitte Wdziekonski,Phi Villageois,Katie Louche,Philippe Collas,Cedric Moro,Christian Dani,Francesc Villarroya,Louis Casteilla +16 more
TL;DR: It is demonstrated that lactate, an important metabolic intermediate, induces browning of murine white adipose cells with expression of functional UCP1, and that the lactate effect on Ucp1 is mediated by intracellular redox modifications as a result of lactate transport through monocarboxylate transporters.
Journal ArticleDOI
Activin A Plays a Critical Role in Proliferation and Differentiation of Human Adipose Progenitors
Laure-Emmanuelle Zaragosi,Brigitte Wdziekonski,Phi Villageois,Mayoura Keophiphath,Marie Maumus,Tamara Tchkonia,Virginie Bourlier,Tala Mohsen-Kanson,Annie Ladoux,Christian Elabd,Marcel Scheideler,Zlatko Trajanoski,Yasuhiro Takashima,Ez-Zoubir Amri,Danièle Lacasa,Coralie Sengenès,Gérard Ailhaud,Karine Clément,Anne Bouloumié,James L. Kirkland,Christian Dani +20 more
TL;DR: A model in which macrophages that are located in adipose tissue regulate adipose progenitor self-renewal through activin A is proposed, which plays a significant role in human adipogenesis.