H
Helen R. Griffiths
Researcher at University of Surrey
Publications - 224
Citations - 9087
Helen R. Griffiths is an academic researcher from University of Surrey. The author has contributed to research in topics: Oxidative stress & Inflammation. The author has an hindex of 50, co-authored 215 publications receiving 8083 citations. Previous affiliations of Helen R. Griffiths include Queen Elizabeth Hospital Birmingham & Glenfield Hospital.
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Journal ArticleDOI
Vitamin C exhibits pro-oxidant properties
Ian D. Podmore,Helen R. Griffiths,Karl E. Herbert,Nalini Mistry,Pratibha Mistry,Joseph Lunec +5 more
TL;DR: It is reported here that vitamin C administered as a dietary supplement to healthy humans exhibits a pro-oxidant, as well as an antioxidant, effect in vivo.
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Monocytes in coronary artery disease and atherosclerosis: where are we now?
Angie Ghattas,Helen R. Griffiths,Andrew Devitt,Gregory Y.H. Lip,Gregory Y.H. Lip,Eduard Shantsila +5 more
TL;DR: The functional role of monocytes and their different subpopulations in Atherosclerosis, acute coronary syndromes, cardiac healing, and recovery is discussed with an aim of critical evaluation of potential future therapeutic targets in atherosclerosis and its complications.
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Novel repair action of vitamin C upon in vivo oxidative DNA damage
Marcus S. Cooke,Mark D. Evans,Ian D. Podmore,Karl E. Herbert,Nalini Mistry,Pratibha Mistry,Peter T. Hickenbotham,Amina Hussieni,Helen R. Griffiths,Joseph Lunec +9 more
TL;DR: The kinetics of 8‐oxo‐2′‐deoxyguanosine removal and processing in vivo are illustrated, for the first time in humans, suggesting a role for vitamin C in the regulation of DNA repair enzymes and thereby demonstrating a non‐scavenging antioxidant effect.
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Antioxidants, reactive oxygen and nitrogen species, gene induction and mitochondrial function.
Malcolm J. Jackson,Sergio Papa,Juan P. Bolaños,Richard Bruckdorfer,Harald Carlsen,Ruan M. Elliott,Jacoba Flier,Helen R. Griffiths,Simon J.R. Heales,Birgit Holst,Michele Lorusso,Elizabeth K. Lund,Jan Øivind Moskaug,Ulrich Moser,Marco Di Paola,M. Cristina Polidori,Anna Signorile,Wilhelm Stahl,José Viña-Ribes,Siân B. Astley +19 more
TL;DR: The role of mitochondrial GSH in the defence against oxidative damage and the importance of reporter mice as tools in antioxidant research are highlighted.
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Systemic Reduction in Glutathione Levels Occurs in Patients with Primary Open-Angle Glaucoma
TL;DR: Patients with glaucoma exhibit low levels of circulating glutathione, suggesting a general compromise of the antioxidative defense.