D
David Stapleton
Researcher at University of Melbourne
Publications - 81
Citations - 9357
David Stapleton is an academic researcher from University of Melbourne. The author has contributed to research in topics: Protein kinase A & Glycogen. The author has an hindex of 41, co-authored 81 publications receiving 8951 citations. Previous affiliations of David Stapleton include Repatriation General Hospital & St. Vincent's Institute of Medical Research.
Papers
More filters
Journal ArticleDOI
AMP-activated protein kinase phosphorylation of endothelial NO synthase
Zhi-Ping Chen,Ken I. Mitchelhill,Belinda J. Michell,David Stapleton,Ignacio Rodríguez-Crespo,Lee A. Witters,David A. Power,Paul R. Ortiz de Montellano,Bruce E. Kemp +8 more
TL;DR: It is shown that AMPK co‐immunoprecipitates with cardiac endothelial NO synthase (eNOS) and phosphorylates Ser‐1177 in the presence of Ca2+‐calmodulin (CaM) to activate eNOS both in vitro and during ischaemia in rat hearts.
Journal ArticleDOI
Mammalian AMP-activated Protein Kinase Subfamily
David Stapleton,Ken I. Mitchelhill,Guang Gao,Jane Widmer,Belinda J. Michell,Trazel Teh,Colin M. House,C. S. Fernandez,T. Cox,Lee A. Witters,Bruce E. Kemp +10 more
TL;DR: Isoforms of the β and γ subunits present in the human genome sequence reveal that the 5′-AMP-activated protein kinase consists of a family of isoenzymes.
Journal ArticleDOI
Coordinated Control of Endothelial Nitric-oxide Synthase Phosphorylation by Protein Kinase C and the cAMP-dependent Protein Kinase
Belinda J. Michell,Zhi-Ping Chen,Tony Tiganis,David Stapleton,Frosa Katsis,David A. Power,Alistair T. R. Sim,Bruce E. Kemp +7 more
TL;DR: Results show that regulation of eNOS activity involves coordinated signaling through Ser-1177 and Thr-495 by multiple protein kinases and phosphatases.
Journal ArticleDOI
Dealing With Energy Demand: The AMP-activated Protein Kinase
Bruce E. Kemp,Ken I. Mitchelhill,David Stapleton,Belinda J. Michell,Zhi-Ping Chen,Lee A. Witters +5 more
TL;DR: The AMP-activated protein kinase yeast homolog, Snf1p, plays a major role in adaption to glucose deprivation, and has diverse roles that extend from energy metabolism through to transcriptional control in mammals.
Journal ArticleDOI
AMP-activated protein kinase, super metabolic regulator.
Bruce E. Kemp,David Stapleton,Duncan J. Campbell,Zhi-Ping Chen,Sid Murthy,M. Walter,Archana Gupta,Julian J. Adams,Frosa Katsis,B.J. van Denderen,Ian G. Jennings,Tristan J. Iseli,Belinda J. Michell,Lee A. Witters +13 more
TL;DR: The AMP-activated protein kinase (AMPK) is a metabolic-stress-sensingprotein kinase that regulates metabolism in response to energy demand and supply by directly phosphorylating rate-limiting enzymes in metabolic pathways as well as controlling gene expression.