W
Wim Robberecht
Researcher at Katholieke Universiteit Leuven
Publications - 214
Citations - 21796
Wim Robberecht is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Amyotrophic lateral sclerosis & Motor neuron. The author has an hindex of 73, co-authored 210 publications receiving 19984 citations. Previous affiliations of Wim Robberecht include Radboud University Nijmegen Medical Centre & Flanders Institute for Biotechnology.
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Journal ArticleDOI
Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration
Bert Oosthuyse,Lieve Moons,Erik Storkebaum,Heike Beck,Dieter Nuyens,Koenraad Brusselmans,J. Van Dorpe,Peter Hellings,M. Gorselink,Stephane Heymans,Gregor Theilmeier,Mieke Dewerchin,Vincent Laudenbach,P. Vermylen,H. Raat,Till Acker,V. Vleminckx,L. Van Den Bosch,Neil R. Cashman,Hajime Fujisawa,Maarten R. Drost,Raf Sciot,F. Bruyninckx,Daniel J. Hicklin,Can Ince,Pierre Gressens,Florea Lupu,Karl H. Plate,Wim Robberecht,Jean-Marc Herbert,Desire Collen,Peter Carmeliet +31 more
TL;DR: The results indicate that chronic vascular insufficiency and, possibly, insufficient Vegf-dependent neuroprotection lead to the select degeneration of motor neurons.
Journal ArticleDOI
Progressive Multifocal Leukoencephalopathy after Natalizumab Therapy for Crohn's Disease
Gert Van Assche,Marc Van Ranst,Raphael Sciot,Bénédicte Dubois,Severine Vermeire,Maja Noman,Jannick Verbeeck,Karel Geboes,Wim Robberecht,Paul Rutgeerts +9 more
TL;DR: Analysis of frozen serum samples showed that JC virus DNA had appeared in the serum three months after the initiation of open-label natalizumab monotherapy and two months before the appearance of symptomatic PML, suggesting that anti-alpha4-integrin therapy can result in JC virus-induced PML.
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VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death
Diether Lambrechts,Erik Storkebaum,Masafumi Morimoto,Jurgen Del-Favero,Frederik Desmet,Stefan L. Marklund,Sabine Wyns,Vincent Thijs,Jörgen Andersson,Ingrid van Marion,Ammar Al-Chalabi,Stéphanie Bornes,Rhiannon Musson,Valerie K. Hansen,Lars Beckman,Rolf Adolfsson,Hardev Pall,Hervé Prats,Severine Vermeire,Paul Rutgeerts,Shigehiro Katayama,Takuya Awata,Nigel Leigh,Loïc Lang-Lazdunski,Mieke Dewerchin,Christopher Shaw,Lieve Moons,Robert Vlietinck,Robert Vlietinck,Karen E. Morrison,Wim Robberecht,Christine Van Broeckhoven,Desire Collen,Peter M. Andersen,Peter Carmeliet +34 more
TL;DR: It is indicated that VEGF is a modifier of motoneuron degeneration in human ALS and unveil a therapeutic potential of Vegfa for stressed motoneurons in mice.
Journal ArticleDOI
The changing scene of amyotrophic lateral sclerosis
TL;DR: New findings in ALS research are summarized, what they have taught us about this disease are discussed and issues that are still outstanding are examined.
Journal ArticleDOI
Mutant small heat-shock protein 27 causes axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy
Oleg V. Evgrafov,Irena Mersiyanova,Joy Irobi,Ludo Van Den Bosch,Ines Dierick,Conrad L. Leung,Olga Schagina,Nathalie Verpoorten,Katrien Van Impe,V P Fedotov,Elena L. Dadali,Michaela Auer-Grumbach,Christian Windpassinger,Klaus Wagner,Zoran Mitrović,David Hilton-Jones,Kevin Talbot,Jean-Jacques Martin,Natalia Vasserman,Svetlana Tverskaya,A. V. Polyakov,Ronald K.H. Liem,Jan Gettemans,Wim Robberecht,Peter De Jonghe,Vincent Timmerman +25 more
TL;DR: A missense mutation in the gene encoding 27-kDa small heat-shock protein B1 (HSPB1, also called HSP27) that segregates in the family with CMT2F is reported and four additional missense mutations are identified.