A
Anna Di Fiore
Researcher at National Research Council
Publications - 62
Citations - 4202
Anna Di Fiore is an academic researcher from National Research Council. The author has contributed to research in topics: Carbonic anhydrase & Enzyme. The author has an hindex of 30, co-authored 58 publications receiving 3761 citations. Previous affiliations of Anna Di Fiore include University of Florence & École nationale supérieure de chimie de Montpellier.
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Journal ArticleDOI
Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms?
Journal ArticleDOI
Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX
Vincenzo Alterio,Mika Hilvo,Anna Di Fiore,Claudiu T. Supuran,Peiwen Pan,Seppo Parkkila,Andrea Scaloni,Jaromir Pastorek,Silvia Pastorekova,Carlo Pedone,Andrea Scozzafava,Simona Maria Monti,Giuseppina De Simone +12 more
TL;DR: On the basis of the structural differences observed between CA IX and the other membrane-associated α-CAs, further prospects for the rational drug design of isozyme-specific CA inhibitors are proposed, given that inhibition of this enzyme shows antitumor activity both in vitro and in vivo.
Journal ArticleDOI
Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes.
Mika Hilvo,Lina Baranauskiene,Anna Maria Salzano,Andrea Scaloni,Daumantas Matulis,Alessio Innocenti,Andrea Scozzafava,Simona Maria Monti,Anna Di Fiore,Giuseppina De Simone,Mikaela Lindfors,Janne Jänis,Jarkko Valjakka,Silvia Pastorekova,Jaromir Pastorek,Markku S. Kulomaa,Henri R. Nordlund,Claudiu T. Supuran,Seppo Parkkila +18 more
TL;DR: Investigations on the oligomerization and stability of the enzymes revealed that both recombinant proteins form dimers that are stabilized by intermolecular disulfide bond(s).
Journal ArticleDOI
Inhibition of carbonic anhydrase IX targets primary tumors, metastases, and cancer stem cells: Three for the price of one.
Claudiu T. Supuran,Vincenzo Alterio,Anna Di Fiore,Katia D’ Ambrosio,Fabrizio Carta,Simona Maria Monti,Giuseppina De Simone +6 more
TL;DR: Aim of this review is to provide a comprehensive state‐of‐the‐art of studies performed on this enzyme, regarding structural, functional, and biomedical aspects, as well as the development of molecules with diagnostic and therapeutic applications for cancer treatment.
Journal ArticleDOI
Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies
Giuseppina De Simone,Anna Di Fiore,Valeria Menchise,Carlo Pedone,Jochen Antel,Angela Casini,Andrea Scozzafava,Wurl Michael,Claudiu T. Supuran +8 more
TL;DR: The antiepileptic drug zonisamide was considered to act as a weak inhibitor of the zinc enzyme carbonic anhydrase (CA, EC 4.2.1) (with a K(I) of 4.3 microM against the cytosolic isozyme II).