A
Anna J. Stevenson
Researcher at University of Edinburgh
Publications - 65
Citations - 1226
Anna J. Stevenson is an academic researcher from University of Edinburgh. The author has contributed to research in topics: dNaM & DNA methylation. The author has an hindex of 13, co-authored 60 publications receiving 589 citations. Previous affiliations of Anna J. Stevenson include Western General Hospital & University College London.
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Journal ArticleDOI
Epigenetic prediction of complex traits and death
Daniel L. McCartney,Robert F. Hillary,Anna J. Stevenson,Stuart J. Ritchie,Rosie M. Walker,Qian Zhang,Stewart W. Morris,Mairead L. Bermingham,Archie Campbell,Alison D. Murray,Heather C. Whalley,Catharine R. Gale,David J. Porteous,Chris Haley,Allan F. McRae,Naomi R. Wray,Peter M. Visscher,Peter M. Visscher,Andrew M. McIntosh,Andrew M. McIntosh,Kathryn L. Evans,Ian J. Deary,Riccardo E. Marioni +22 more
TL;DR: DNAm predictors correlate with lifestyle factors that are associated with health and mortality and may supplement DNAm-based predictors of age to identify the lifestyle profiles of individuals and predict disease risk.
Journal ArticleDOI
Amyloid Beta and Tau Cooperate to Cause Reversible Behavioral and Transcriptional Deficits in a Model of Alzheimer's Disease.
Eleanor K. Pickett,Abigail G. Herrmann,Jamie McQueen,Kimberly Abt,Owen Dando,Jane Tulloch,Pooja Jain,Sophie Dunnett,Sadaf Sohrabi,Maria P. Fjeldstad,Will Calkin,Leo Murison,Rosemary J. Jackson,Makis Tzioras,Anna J. Stevenson,Marie d'Orange,Monique Hooley,Caitlin Davies,Martí Colom-Cadena,Alejandro Anton-Fernandez,Declan King,Iris Oren,Jamie Rose,C. McKenzie,Elizabeth Allison,Colin Smith,Oliver Hardt,Christopher M. Henstridge,Giles E. Hardingham,Tara L. Spires-Jones +29 more
TL;DR: It is found that Aβ and tau work cooperatively to cause a hyperactivity behavioral phenotype and to cause downregulation of transcription of genes involved in synaptic function, suggesting that lowering synaptic tau levels may be beneficial in AD.
Journal ArticleDOI
Investigating the relationship between DNA methylation age acceleration and risk factors for Alzheimer's disease
Daniel L. McCartney,Anna J. Stevenson,Rosie M. Walker,Jude Gibson,Stewart W. Morris,Archie Campbell,Alison D. Murray,Heather C. Whalley,David J. Porteous,Andrew M. McIntosh,Andrew M. McIntosh,Kathryn L. Evans,Ian J. Deary,Riccardo E. Marioni +13 more
TL;DR: The relationship between the epigenetic clock and AD risk factors is assessed and it is found that methylation-based estimates of biological age and chronological age are correlated with chronological age.
Journal ArticleDOI
Epigenetic measures of ageing predict the prevalence and incidence of leading causes of death and disease burden.
Robert F. Hillary,Anna J. Stevenson,Daniel L. McCartney,Archie Campbell,Rosie M. Walker,David M. Howard,David M. Howard,Craig W. Ritchie,Steve Horvath,Caroline Hayward,Andrew M. McIntosh,David J. Porteous,Ian J. Deary,Kathryn L. Evans,Riccardo E. Marioni +14 more
TL;DR: The data suggest that epigenetic measures of ageing may have utility in clinical settings to complement gold-standard methods for disease assessment and management.
Journal ArticleDOI
Cognitive impairment in sporadic cerebral small vessel disease: A systematic review and meta-analysis.
Olivia K.L. Hamilton,Ellen V. Backhouse,Esther Janssen,Angela C. C. Jochems,Caragh Maher,Tuula E. Ritakari,Anna J. Stevenson,Lihua Xia,Ian J. Deary,Joanna M. Wardlaw +9 more
TL;DR: It is hypothesize that SVD affects all major domains of cognitive ability, and identifies low levels of education as a potentially modifiable risk factor for SVD‐related cognitive impairment.