Anna Kirstein

TL;DR: In this paper, the authors reviewed the pathophysiology and pharmacotherapy of obesity including intersection points to the new generation of antidiabetic drugs and provided insight into the effectiveness of currently approved anti-obesity drugs and other therapeutic avenues that can be explored.

TL;DR: Since alpelisib was well tolerated in first clinical trials, this drug alone or in combination with rapamycin is a potential new treatment option for PHTS-related adipose tissue overgrowth.

TL;DR: It was found that both cellular life span and the capacity for adipocyte differentiation as well as adipocyte-specific functions were preserved in LipPD1 and comparable to SGBS adipocytes.

TL;DR: In this article, the role of PTEN in adipose tissue development was investigated and RNA-Seq of control and PTEN knockdown APCs was performed. And the results provided evidence that PTEN is involved in the regulation of APC proliferation, differentiation, and senescence.

TL;DR: In this article, the role of PTEN in adipose tissue development was investigated and RNA sequencing of control and PTEN knockdown APCs was performed and it was shown that reducing PTEN levels using siRNA or CRISPR leads to an enhanced proliferation and differentiation of APCs.