M
Martha Hanschkow
Researcher at Leipzig University
Publications - 5
Citations - 25
Martha Hanschkow is an academic researcher from Leipzig University. The author has contributed to research in topics: Adipogenesis & Adipose tissue. The author has an hindex of 1, co-authored 4 publications receiving 2 citations.
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Journal ArticleDOI
In Depth Quantitative Proteomic and Transcriptomic Characterization of Human Adipocyte Differentiation using the SGBS Cell Line
Stefan Kalkhof,Laura Krieg,Petra Büttner,Martin Wabitsch,Carolin Küntzel,D Friebe,Kathrin Landgraf,Martha Hanschkow,Kristin Schubert,Wieland Kiess,Knut Krohn,Matthias Blüher,Martin von Bergen,Martin von Bergen,Antje Körner +14 more
TL;DR: A comprehensive analysis of combined transcriptomic and proteomic alterations during adipocyte differentiation in Simpson–Golabi–Behmel Syndrome (SGBS) cells is provided and provides a deep molecular profile of adipogenesis that will support future studies to understand adipocyte function.
Journal ArticleDOI
PTEN regulates adipose progenitor cell growth, differentiation, and replicative aging.
Anna Kirstein,Stephanie Kehr,Michèle Nebe,Martha Hanschkow,Lisa A.G. Barth,Judith Lorenz,Melanie Penke,Jana Breitfeld,Diana Le Duc,Diana Le Duc,Kathrin Landgraf,Antje Körner,Peter Kovacs,Peter F. Stadler,Peter F. Stadler,Wieland Kiess,Antje Garten,Antje Garten +17 more
TL;DR: In this article, the role of PTEN in adipose tissue development was investigated and RNA-Seq of control and PTEN knockdown APCs was performed. And the results provided evidence that PTEN is involved in the regulation of APC proliferation, differentiation, and senescence.
Journal ArticleDOI
Expression of the adipocyte progenitor markers MSCA1 and CD36 is associated with adipose tissue function in children.
Martha Hanschkow,Nathalie Boulet,Elena Kempf,Anne Bouloumié,Wieland Kiess,Robert Stein,Antje Körner,Kathrin Landgraf +7 more
TL;DR: In this paper, MSCA1 and cluster of differentiation 36 (CD36) were found to be associated with obesity-related alterations in adipose tissue (AT) development in children.
Journal ArticleDOI
Aberrant expression of agouti signaling protein (ASIP) as a cause of monogenic severe childhood obesity
Elena Vanessa Caroline Kempf,Kathrin Landgraf,Robert Stein,Martha Hanschkow,Anja Hilbert,Rami Abou Jamra,Paula Boczki,Gunda Herberth,Andreas Kühnapfel,Yu-Hua Tseng,Claudia Stäubert,Torsten Schöneberg,Peter Kühnen,Nigel W. Rayner,Eleftheria Zeggini,Wieland Kiess,Matthias Blüher,Antje Körner +17 more
TL;DR: In this article , a heterozygous tandem duplication at the ASIP (agouti signaling protein) gene locus causing ubiquitous, ectopic ASIP expression in a female patient with extreme childhood obesity was reported.
Posted ContentDOI
PTEN regulates adipocyte progenitor growth, differentiation and replicative aging
Anna Kirstein,Stephanie Kehr,Michèle Nebe,Martha Hanschkow,Judith Lorenz,Melanie Penke,Jana Breitfeld,Diana Le Duc,Diana Le Duc,Kathrin Landgraf,Antje Körner,Peter Kovacs,Peter F. Stadler,Peter F. Stadler,Wieland Kiess,Antje Garten,Antje Garten +16 more
TL;DR: In this article, the role of PTEN in adipose tissue development was investigated and RNA sequencing of control and PTEN knockdown APCs was performed and it was shown that reducing PTEN levels using siRNA or CRISPR leads to an enhanced proliferation and differentiation of APCs.