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Anna Kirstein
Researcher at Leipzig University
Publications - 18
Citations - 57
Anna Kirstein is an academic researcher from Leipzig University. The author has contributed to research in topics: PTEN & Medicine. The author has an hindex of 2, co-authored 10 publications receiving 16 citations.
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Journal ArticleDOI
Obesity-An Update on the Basic Pathophysiology and Review of Recent Therapeutic Advances.
Erind Gjermeni,Anna Kirstein,Florentien Kolbig,Michael Kirchhof,Linnaeus Bundalian,Julius L. Katzmann,Ulrich Laufs,Matthias Blüher,Antje Garten,Diana Le Duc,Diana Le Duc +10 more
TL;DR: In this paper, the authors reviewed the pathophysiology and pharmacotherapy of obesity including intersection points to the new generation of antidiabetic drugs and provided insight into the effectiveness of currently approved anti-obesity drugs and other therapeutic avenues that can be explored.
Journal ArticleDOI
The Novel Phosphatidylinositol-3-Kinase (PI3K) Inhibitor Alpelisib Effectively Inhibits Growth of PTEN-Haploinsufficient Lipoma Cells
Anna Kirstein,Adrien Augustin,Adrien Augustin,Melanie Penke,Michele Cea,Antje Körner,Wieland Kiess,Antje Garten,Antje Garten +8 more
TL;DR: Since alpelisib was well tolerated in first clinical trials, this drug alone or in combination with rapamycin is a potential new treatment option for PHTS-related adipose tissue overgrowth.
Journal ArticleDOI
A new human adipocyte model with PTEN haploinsufficiency
Franziska Kässner,Anna Kirstein,Norman Händel,Gordian L. Schmid,Kathrin Landgraf,A. Berthold,Astrid Tannert,Michael Schaefer,Martin Wabitsch,Wieland Kiess,Antje Körner,Antje Garten,Antje Garten +12 more
TL;DR: It was found that both cellular life span and the capacity for adipocyte differentiation as well as adipocyte-specific functions were preserved in LipPD1 and comparable to SGBS adipocytes.
Journal ArticleDOI
PTEN regulates adipose progenitor cell growth, differentiation, and replicative aging.
Anna Kirstein,Stephanie Kehr,Michèle Nebe,Martha Hanschkow,Lisa A.G. Barth,Judith Lorenz,Melanie Penke,Jana Breitfeld,Diana Le Duc,Diana Le Duc,Kathrin Landgraf,Antje Körner,Peter Kovacs,Peter F. Stadler,Peter F. Stadler,Wieland Kiess,Antje Garten,Antje Garten +17 more
TL;DR: In this article, the role of PTEN in adipose tissue development was investigated and RNA-Seq of control and PTEN knockdown APCs was performed. And the results provided evidence that PTEN is involved in the regulation of APC proliferation, differentiation, and senescence.
Posted ContentDOI
PTEN regulates adipocyte progenitor growth, differentiation and replicative aging
Anna Kirstein,Stephanie Kehr,Michèle Nebe,Martha Hanschkow,Judith Lorenz,Melanie Penke,Jana Breitfeld,Diana Le Duc,Diana Le Duc,Kathrin Landgraf,Antje Körner,Peter Kovacs,Peter F. Stadler,Peter F. Stadler,Wieland Kiess,Antje Garten,Antje Garten +16 more
TL;DR: In this article, the role of PTEN in adipose tissue development was investigated and RNA sequencing of control and PTEN knockdown APCs was performed and it was shown that reducing PTEN levels using siRNA or CRISPR leads to an enhanced proliferation and differentiation of APCs.