Anna La Torre

TL;DR: Three microRNAs, let-7, micro RNA-125, and microRNA-9, serve as key regulators of the early to late developmental transition in retinal progenitors and demonstrate how progenitor temporal identity is controlled, a finding that will impact efforts to generate specific neural types from pluripotent stem cells.

TL;DR: Three key epochs are defined in the transcriptome dynamics of human retina from fetal day (D) 52 to 136 to confirm the cellular basis of transcriptional changes and highlight the dramatic acceleration of development in the fovea compared with peripheral retina.

TL;DR: It is shown that Netrin 1 regulates, both in vivo and in vitro, mode I MAP1B phosphorylation, which controlsMAP1B activity, in a signaling pathway that depends essentially on the kinases GSK3 and CDK5 and that map1B-deficient neurons from the lower rhombic lip and other brain regions have reduced chemoattractive responses to Netrin 2 in vitro.

TL;DR: It is shown that Reelin can induce mode I MAP1B phosphorylation, both in vivo and in vitro, through gsk3 and cdk5 activation, and proposed that this could correlate with its function in neuronal migration.

TL;DR: Targeted viral expression of GPR88 in MSNs rescued the molecular and electrophysiological properties and normalized behavior, suggesting that aberrant MSN activation in the absence of G PR88 underlies behavioral deficits and its dysfunction may contribute to behaviors observed in neuropsychiatric disease.