Showing papers in "International Immunopharmacology in 2010"

TL;DR: The present review is intended to highlight the emerging role of neutrophils in the regulation of both innate and adaptive immunity during acute infectious or inflammatory conditions.

TL;DR: Some recent literature on the mechanisms of immunomodulation by MSC in vitro and animal models are reviewed, new data on the secretion of pro-inflammatory and anti-inflammatory cytokines, chemokines and prostaglandins are presented and the hopes and expectations of MSC-based immune therapy are discussed.

TL;DR: If BR is orally administered, its main constituent, C3G, may be metabolized to cyanidin and/or PA, which express potent anti-inflammatory effects by regulating NF-kappaB and MAPK activation.

TL;DR: The results suggest that curcumin can effectively suppress inflammatory response by inhibiting pro-inflammatory mediators and regulating humoral and cellular immune responses.

TL;DR: The results indicate that the inhibitory effect of cordycepin on LPS-stimulated inflammatory mediator production in BV2 microglia is associated with the suppression of the NF-κB, Akt, and MAPK signaling pathways and may be useful in treating neurodegenerative diseases.

TL;DR: The findings suggest that combined training has useful anti-inflammatory effects by decrease in PBMC and plasma IL-17 production and the disability score was significantly decreased in test MS subjects after 8 weeks combined exercise training.

TL;DR: Results suggested that the L. pentosus strain S-PT84 showed inhibitory activity against influenza virus infection in mice, suggesting that the immune response could be activated by intranasal administration of S- PT84 in the respiratory immune system and protected against influenza viruses infection.

TL;DR: The discovery that icariin significantly inhibited the release of nitric oxide, prostaglandin E (PGE)-2, reactive oxygen species (ROS) and mRNA expression of proinflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 in lipopolysaccharide (LPS)-activated microglia in neuron-microglia co-culture system is reported.

TL;DR: There were significant increases in phagocyte and thymus indexes, spleen index, hemolytic activity as well as spleen antibody production and delayed type hypersensitivity in mice, suggesting that CS-PCS3-II could significantly enhance immunpotentiation in mice.

TL;DR: Results suggest that the sulfated SPS-CF isolated from C. fulvescens has potent immunostimulating activity.

TL;DR: Genipin is suggested to provide neuroprotection by reducing the production of various neurotoxic molecules from activated microglia by inhibiting LPS-induced nitric oxide release from cultured rat brain microglial cells.

TL;DR: Diosgenin reduces the production of inflammatory meditators by inhibiting LPS/IFN-gamma-triggered CK2, JNK, NF-kappaB and AP-1 activation, thereby implicating a mechanism by which diosgenin may exert its immunosuppressive effects.

TL;DR: It is concluded that curcumin alone may have limited anti-bactericidal effect on H. pylori, and on the production of inflammatory cytokines, and the use of curcuming in combination with therapeutic regimens may be beneficial as an alternative treatment.

TL;DR: Results indicate that the two major proteins QR-2 and QR-1 present in a ratio of 4:1 in raw garlic contribute to garlic's immunomodulatory activity, and their characteristics are markedly similar to the abundant Allium sativum agglutinins (ASA) I and II, respectively.

TL;DR: This study investigated whether LAB can improve the polarization of Th1/Th2 cytokines and autophagic ability of mononuclear phagocytes in response to Mtb antigen, leading to synergistic increase in IFN-gamma, and an additive increase in NO.

TL;DR: The results demonstrated that AP1, AP2 and AP3 exhibited the anti-inflammatory effect by interfering COX and inflammatory cytokines and the underlying mechanisms of AP2 may be related to down-expression of genes involved in inflammatory cascade.

TL;DR: DMC exerts its in vitro anti-inflammatory effect in LPS-activated N9 microglial cells by blocking nuclear factor-kappaB (NF-kappB) and MAPKs activation, which may be partly due to its potent down-regulation of the NADPH-derived iROS production.

TL;DR: 25-D3 reduced DC capacity to induce proliferation of antigen-specific T cells and DC chemotaxis towards chemokine (CC) ligand 21, indicating that 25-D 3 has a regulating function following intrinsic 1 alpha-hydroxylation, a mechanism that potentially has an immunomodulatory effect in vivo.

TL;DR: The results suggest that the anti-inflammatory effect of sulfuretin in LPS-treated RAW 264.7 macrophages is associated with the suppression of NF-kappaB transcriptional activity via the inhibitory regulation of IKKbeta phosphorylation.

TL;DR: The possibility that the use of Sorafenib as cancer therapy could potentially reverse the immunosuppressive cytokine profile of tumor-associated macrophages, rendering the tumor microenvironment more conducive to an anti-tumor immune response is raised.

TL;DR: In mice, PFOA- and PFOS-induced hepatomegaly is associated with significant alterations in hepatic histophysiology and immune status, as well as induction of hepatic erythropoiesis.

TL;DR: It is shown that mice given Wy-14643 were less susceptible to experimental acute colitis induced by DSS, and this decreased susceptibility was correlated with decreased production of IFNγ, IL-1β, IL -6, and TNF-α.

TL;DR: CsA-induced oxidative stress leads to the structural and functional damages in the testicular tissue and sperm quality of rats, and also EA has a protective effect on these damages.

TL;DR: It is found that artesunate (AS) could protect mice against a lethal challenge with heat-killed S. aureus in a dose-dependent manner, and AS in combination with ampicillin sodium-sulbactam sodium (AMPS) could further increase survival of mice challenged with live S.aureus than AMPS alone.

TL;DR: The results suggest that astaxanthin regulates IL-6 production through a p-ERK1/2-MSK-1- and p-NF-κB p65-dependent pathway in activated microglial cells.

TL;DR: Investigation of the effect of the purified lectin from the green marine alga Caulerpa cupressoides in classical models of nociception and inflammation found it appears to have important antinociceptive and anti-inflammatory activities and could represent an important agent for future studies.

TL;DR: The combination of quercetin as a food supplement adjunctive with intratumoral doxorubicin chemotherapy may represent a novel and highly effective strategy for inducing immune responses against tumors.

TL;DR: Irregular changes in cytokine production and immune cell populations due to TBBPA treatment were suggested to cause exacerbation of pneumonia in RSV-infected mice.

TL;DR: Considering the adjuvant effect demonstrated in this study, ginsenoside Re deserve further studies for improving the quality of vaccines where mixed Th1/Th2 immune responses are needed.

TL;DR: It is suggested that betulinic acid inhibited IL-6 production by preventing p65 NF-kappaBnuclear translocation and there is a possibility that this prevention of p65 nuclear translocation may involve p38 and ERK MAPKs as cross talks occur between MAPK and NF- kappaB pathways.