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Anna Paola Pelliccioli
Researcher at Novartis
Publications - 6
Citations - 780
Anna Paola Pelliccioli is an academic researcher from Novartis. The author has contributed to research in topics: Flash photolysis & Protecting group. The author has an hindex of 5, co-authored 6 publications receiving 728 citations. Previous affiliations of Anna Paola Pelliccioli include University of Basel & Masaryk University.
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Journal ArticleDOI
Photoremovable protecting groups: reaction mechanisms and applications
TL;DR: Progress will depend on the development of photoremovable protecting groups that satisfy the diverse requirements of new applications--a challenging task for photochemists.
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2,5-Dimethylphenacyl Esters: A Photoremovable Protecting Group for Carboxylic Acids†
TL;DR: In this paper, the 2,5-dimethylphenacyl (DMP) esters (1a−c) in benzene or cyclohexane solutions produce the corresponding free carboxylic acids in high chemical yields, along with 6-methyl-1-indanone (3).
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Photorelease of HCl from o-methylphenacyl chloride proceeds through the Z-xylylenol.
TL;DR: Photorelease of HCl from 2,5-dimethylphenacyl chloride was studied by nanosecond laser flash photolysis and both the E- and Z-photoenols are formed, but only the E isomer gives product 3 by HCl elimination whereas the Z-isomer decays predominantly by intramolecular reketonization to 1 in this solvent.
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2,5-Dimethylphenacyl esters: A photoremovable protecting group for phosphates and sulfonic acids
TL;DR: In this article, the chromophore is proposed as an excellent photoremovable protecting group for use in organic synthesis and biochemistry, and its lifetime of 20 and 25 µs is determined by laser flash photolysis.
Journal ArticleDOI
Evolution of Novartis’ Small Molecule Screening Deck Design
Ansgar Schuffenhauer,Nadine Schneider,Samuel Hintermann,Douglas S. Auld,Jutta Blank,Simona Cotesta,Caroline Engeloch,Nikolas Fechner,Christoph Gaul,Jerome Giovannoni,Johanna M. Jansen,John Joslin,Philipp Krastel,Eugen Lounkine,John I. Manchester,Lauren G. Monovich,Anna Paola Pelliccioli,Manuel Schwarze,Michael Shultz,Nikolaus Stiefl,Daniel K. Baeschlin +20 more
TL;DR: This article summarizes the evolution of the screening deck at the Novartis Institutes for BioMedical Research (NIBR) and found that using traditional leadlikeness criteria reduces the hit rates of attractive chemical starting points in subset screening.