Anna Santamaria

TL;DR: Intriguingly, intracellular-clusterin was localized exclusively in the cytoplasm in stably transfected cells, suggesting a negative correlation between nuclear clusterin accumulation and cell survival, and suggesting that clusterin might be a proapoptotic or a survival gene.

TL;DR: It is shown that PTOV1 interacts with the lipid raft protein flotillin-1, with which it copurifies in detergent-insoluble floating fractions and that both proteins are required for cell proliferation.

TL;DR: The Standard protocol was the best performing procedure since the other two tested protocols did not ameliorate neither yield nor purity of exosome-like vesicles, and contributes to establishing the basis for future comparative studies to foster the field of biomarker research in gynecology.

TL;DR: A comprehensive review of the different methods for normalising the levels of specific miRNAs present in saliva, as this is a critical step in their analysis, and the challenge to validate salivary miRNA deregulation as a reality to manage cancer patients is provided.

TL;DR: The tumor suppressor function of miR-654-5p is unveiled, suggesting that its restoration or co-targeting of CDCP1 and PLAGL2 may be an effective therapeutic approach for ovarian cancer.