A
Anna Sapone
Researcher at Harvard University
Publications - 49
Citations - 6290
Anna Sapone is an academic researcher from Harvard University. The author has contributed to research in topics: Intestinal permeability & Zonulin. The author has an hindex of 24, co-authored 43 publications receiving 5260 citations. Previous affiliations of Anna Sapone include Beth Israel Deaconess Medical Center & Seconda Università degli Studi di Napoli.
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Journal ArticleDOI
Spectrum of gluten-related disorders: consensus on new nomenclature and classification
Anna Sapone,Anna Sapone,Julio C. Bai,Carolina Ciacci,Jernej Dolinsek,Peter H.R. Green,Marios Hadjivassiliou,Katri Kaukinen,Kamran Rostami,David S Sanders,Michael Schumann,Reiner Ullrich,Danilo Villalta,Umberto Volta,Carlo Catassi,Carlo Catassi,Alessio Fasano +16 more
TL;DR: This review will summarize the current knowledge about the three main forms of gluten reactions: allergic (wheat allergy), autoimmune (celiac disease, dermatitis herpetiformis and gluten ataxia) and possibly immune-mediated (gluten sensitivity), and also outline pathogenic, clinical and epidemiological differences and propose new nomenclature and classifications.
Journal ArticleDOI
Celiac disease: a comprehensive current review
Giacomo Caio,Giacomo Caio,Umberto Volta,Anna Sapone,Anna Sapone,Daniel A. Leffler,Daniel A. Leffler,Roberto De Giorgio,Carlo Catassi,Carlo Catassi,Alessio Fasano +10 more
TL;DR: The present review is timely and provides a thorough appraisal of various aspects characterizing celiac disease, and the identification of alternative or complementary treatments to the gluten-free diet brings hope for patients unavoidably burdened by diet restrictions.
Journal ArticleDOI
Zonulin Upregulation Is Associated With Increased Gut Permeability in Subjects With Type 1 Diabetes and Their Relatives
Anna Sapone,Laura de Magistris,Michelle Pietzak,Maria Grazia Clemente,Amit Tripathi,Francesco Cucca,Rosanna Lampis,Deborah Kryszak,Maria Cartenì,Maddalena Generoso,Dario Iafusco,Francesco Prisco,Francesca Laghi,Gabriele Riegler,Romano Carratù,Debra Counts,Alessio Fasano +16 more
TL;DR: Zonulin upregulation seems to precede the onset of the disease, providing a possible link between increased intestinal permeability, environmental exposure to non–self antigens, and the development of autoimmunity in genetically susceptible individuals.
Journal ArticleDOI
Alterations of the intestinal barrier in patients with autism spectrum disorders and in their first-degree relatives.
Laura de Magistris,Valeria Familiari,Antonio Pascotto,Anna Sapone,Alessandro Frolli,Patrizia Iardino,Maria Cartenì,Mario De Rosa,Ruggiero Francavilla,Gabriele Riegler,Roberto Militerni,Carmela Bravaccio +11 more
TL;DR: It is indicated that measuring IPT could help to identify a subgroup of patients with autism who could benefit from a gluten-free diet and indicate the presence of an intestinal (tight-junction linked) hereditary factor in the families of subjects with autism.
Journal ArticleDOI
Divergence of gut permeability and mucosal immune gene expression in two gluten-associated conditions: celiac disease and gluten sensitivity
Anna Sapone,Anna Sapone,Karen M. Lammers,Vincenzo Casolaro,Vincenzo Casolaro,Marcella Cammarota,Maria Teresa Giuliano,Mario De Rosa,Rosita Stefanile,Giuseppe Mazzarella,Carlo Tolone,Maria Itria Russo,Pasquale Esposito,Franca Ferraraccio,Maria Cartenì,Gabriele Riegler,Laura de Magistris,Alessio Fasano +17 more
TL;DR: This study shows that the two gluten-associated disorders, CD and GS, are different clinical entities, and it contributes to the characterization of GS as a condition associated with prevalent gluten-induced activation of innate, rather than adaptive, immune responses in the absence of detectable changes in mucosal barrier function.