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Annalene Nel
Researcher at International Partnership for Microbicides
Publications - 40
Citations - 2429
Annalene Nel is an academic researcher from International Partnership for Microbicides. The author has contributed to research in topics: Dapivirine & Vaginal ring. The author has an hindex of 19, co-authored 39 publications receiving 2094 citations. Previous affiliations of Annalene Nel include National Institutes of Health.
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Journal ArticleDOI
Use of a Vaginal Ring Containing Dapivirine for HIV-1 Prevention in Women
Jared M. Baeten,Thesla Palanee-Phillips,Elizabeth R. Brown,Elizabeth R. Brown,Katie Schwartz,Lydia Soto-Torres,Vaneshree Govender,Nyaradzo Mgodi,Flavia Matovu Kiweewa,Gonasagrie Nair,Felix Mhlanga,Samantha Siva,Linda-Gail Bekker,Nitesha Jeenarain,Zakir Gaffoor,Francis Martinson,Bonus Makanani,Arendevi Pather,Logashvari Naidoo,Marla Husnik,Marla Husnik,Barbra A. Richardson,Barbra A. Richardson,Urvi M. Parikh,John W. Mellors,Mark A. Marzinke,Craig W. Hendrix,Ariane van der Straten,Ariane van der Straten,Gita Ramjee,Zvavahera M. Chirenje,Clemensia Nakabiito,Taha E. Taha,Judith G. Jones,Ashley J Mayo,Rachel Scheckter,Jennifer Berthiaume,Edward Livant,Cindy Jacobson,Patrick Ndase,Rhonda White,Karen Patterson,Donna Germuga,Beth Galaska,Katherine E. Bunge,Devika Singh,Daniel W. Szydlo,Elizabeth T. Montgomery,Barbara S. Mensch,Kristine Torjesen,Cynthia I. Grossman,Nahida Chakhtoura,Annalene Nel,Zeda F. Rosenberg,Ian McGowan,Sharon L. Hillier +55 more
TL;DR: A monthly vaginal ring containing dapivirine reduced the risk of HIV-1 infection among African women, with increased efficacy in subgroups with evidence of increased adherence.
Journal ArticleDOI
Safety and Efficacy of a Dapivirine Vaginal Ring for HIV Prevention in Women
Annalene Nel,Neliëtte van Niekerk,Saidi Kapiga,Linda-Gail Bekker,Cynthia Gama,Katherine Gill,Anatoli Kamali,Philip Kotze,Cheryl Louw,Zonke Mabude,Nokuthula Miti,Sylvia Kusemererwa,Hugo Tempelman,Hannelie Carstens,Brid Devlin,Michelle Isaacs,Mariëtte Malherbe,Winel Mans,Jeremy Nuttall,Marisa Russell,Smangaliso Ntshele,Marlie Smit,Leonard Solai,Patrick Spence,John Steytler,Kathleen Windle,Maarten Borremans,Sophie Resseler,Jens Van Roey,Wim Louis Julien Parys,Tony Vangeneugden,Ben van Baelen,Zeda F. Rosenberg,Ring Study Team +33 more
TL;DR: Among women in sub-Saharan Africa, the dapivirine ring was not associated with any safety concerns and was associated with a rate of acquisition of HIV-1 infection that was lower than the rate with placebo.
Journal ArticleDOI
Safety and pharmacokinetics of dapivirine delivery from matrix and reservoir intravaginal rings to HIV-negative women.
Annalene Nel,Shanique C Smythe,Katherine Young,Karl Malcolm,Clare McCoy,Zeda F. Rosenberg,Joseph Romano +6 more
TL;DR: Vaginal microbicides for the prevention of HIV transmission may be an important option for protecting women from infection as mentioned in this paper, and incorporation of dapivirine, a lead candidate non-nucleoside reverse transcriptase inhibitor, into intravaginal rings (IVRs) for sustained mucosal delivery may increase microbic
Safety and Pharmacokinetics of Dapivirine Delivery From Matrix and Reservoir Intravaginal Rings to HIV-Negative Women
Annalene Nel,Shanique C Smythe,Katherine Young,Karl Malcolm,Clare McCoy,Zeda F. Rosenberg,Joseph Romano +6 more
TL;DR: Both IVR types were safe and well tolerated with similar adverse events observed in the placebo and dapivirine groups, suggesting that IVR delivery of microbicides is a viable option meriting further study.
Journal ArticleDOI
Phase 1 Safety, Pharmacokinetics, and Pharmacodynamics of Dapivirine and Maraviroc Vaginal Rings: A Double-Blind Randomized Trial.
Beatrice A. Chen,Lori Panther,Mark A. Marzinke,Craig W. Hendrix,Craig J. Hoesley,Ariane van der Straten,Marla Husnik,Lydia Soto-Torres,Annalene Nel,Sherri Johnson,Nicola Richardson-Harman,Lorna K. Rabe,Charlene S. Dezzutti +12 more
TL;DR: In this first study of a combination microbicide vaginal ring, all 4 rings were safe and well tolerated and DPV, but not MVC, demonstrated concentration-dependent inhibition of HIV-1 infection in cervical tissue.