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Anne Desmazières
Researcher at University of Paris
Publications - 22
Citations - 839
Anne Desmazières is an academic researcher from University of Paris. The author has contributed to research in topics: Myelin & Node of Ranvier. The author has an hindex of 15, co-authored 22 publications receiving 660 citations. Previous affiliations of Anne Desmazières include Pierre-and-Marie-Curie University & Centre national de la recherche scientifique.
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Journal ArticleDOI
A Critical Role for Neurofascin in Regulating Action Potential Initiation through Maintenance of the Axon Initial Segment
Barbara Zonta,Anne Desmazières,Arianna Rinaldi,Steven Tait,Diane L. Sherman,Matthew F. Nolan,Peter J. Brophy +6 more
TL;DR: It is proposed that Nfasc186 optimizes communication between mature neurons by anchoring the key elements of the adult AIS complex, which is critical for the initiation and propagation of action potentials.
Journal ArticleDOI
Rapid Disruption of Axon–Glial Integrity in Response to Mild Cerebral Hypoperfusion
Michell M. Reimer,Jamie McQueen,Luke Searcy,Gillian Scullion,Barbara Zonta,Anne Desmazières,Philip R. Holland,Jessica Smith,Catherine M. Gliddon,Emma R. Wood,Pawel Herzyk,Peter J. Brophy,James McCulloch,Karen Horsburgh +13 more
TL;DR: It is demonstrated that hypoperfusion leads to a rapid disruption of key proteins critical to the stability of the axon–glial connection that is mediated by a diversity of molecular events.
Journal ArticleDOI
Mechanisms of sodium channel clustering and its influence on axonal impulse conduction
Sean A. Freeman,Sean A. Freeman,Sean A. Freeman,Anne Desmazières,Anne Desmazières,Anne Desmazières,Desdemona Fricker,Desdemona Fricker,Desdemona Fricker,Catherine Lubetzki,Nathalie Sol-Foulon,Nathalie Sol-Foulon,Nathalie Sol-Foulon +12 more
TL;DR: This comprehensive review summarizes the mechanisms governing the clustering of sodium channels at the peripheral and central nervous system nodes and the specific roles of their clustering in influencing action potential conduction and highlights the classical biophysical parameters implicated in conduction timing.
Journal ArticleDOI
Acceleration of conduction velocity linked to clustering of nodal components precedes myelination.
Sean A. Freeman,Sean A. Freeman,Sean A. Freeman,Anne Desmazières,Anne Desmazières,Anne Desmazières,Jean Simonnet,Jean Simonnet,Jean Simonnet,Marie Gatta,Marie Gatta,Marie Gatta,Friederike Pfeiffer,Friederike Pfeiffer,Friederike Pfeiffer,Marie Stéphane Aigrot,Marie Stéphane Aigrot,Marie Stéphane Aigrot,Quentin Rappeneau,Quentin Rappeneau,Quentin Rappeneau,Serge Guerreiro,Serge Guerreiro,Serge Guerreiro,Patrick P. Michel,Patrick P. Michel,Patrick P. Michel,Yuchio Yanagawa,Gilles Barbin,Gilles Barbin,Gilles Barbin,Peter J. Brophy,Desdemona Fricker,Desdemona Fricker,Desdemona Fricker,Catherine Lubetzki,Nathalie Sol-Foulon,Nathalie Sol-Foulon,Nathalie Sol-Foulon +38 more
TL;DR: It is shown that prenodes are restricted to GABAergic neurons, whereas clustering of nodal proteins only occurs concomitantly with myelin ensheathment on pyramidal neurons, implying separate mechanisms of assembly among different neuronal subpopulations.
Journal ArticleDOI
Live Imaging of Targeted Cell Ablation in Xenopus: A New Model to Study Demyelination and Repair
Ferdinand Kaya,Abdelkrim Mannioui,Abdelkrim Mannioui,Abdelkrim Mannioui,Albert Chesneau,Sowmya Sekizar,Sowmya Sekizar,Sowmya Sekizar,Emmanuelle Maillard,Chantal Ballagny,Ludivine Houel-Renault,David DuPasquier,Odile Bronchain,Isabelle Holtzmann,Anne Desmazières,Anne Desmazières,Anne Desmazières,Jean-Leon Thomas,Barbara A. Demeneix,Peter J. Brophy,Bernard Zalc,André Mazabraud +21 more
TL;DR: The Xenopus pMBP-eGFP-NTR line is established as a novel in vivo model for the study of demyelination/remyelination processes and for large-scale screens of therapeutic agents promoting myelin repair.