A
Anne Elizabeth Rosser
Researcher at Cardiff University
Publications - 261
Citations - 10215
Anne Elizabeth Rosser is an academic researcher from Cardiff University. The author has contributed to research in topics: Huntington's disease & Transplantation. The author has an hindex of 49, co-authored 238 publications receiving 9149 citations. Previous affiliations of Anne Elizabeth Rosser include University College London & Cambridge University Hospitals NHS Foundation Trust.
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Journal ArticleDOI
A new method for the rapid and long term growth of human neural precursor cells
Clive N. Svendsen,M. G. ter Borg,Richard J. E. Armstrong,Anne Elizabeth Rosser,Siddharthan Chandran,Thor Ostenfeld,Maeve A. Caldwell +6 more
TL;DR: This simple and novel culture method allows the rapid expansion of large numbers of non-transformed human neural precursor cells which may be of use in drug discovery, ex vivo gene therapy and clinical neural transplantation.
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Long-Term Survival of Human Central Nervous System Progenitor Cells Transplanted into a Rat Model of Parkinson's Disease ☆
Clive N. Svendsen,Maeve A. Caldwell,Jinkun Shen,Melanie G. ter Borg,Anne Elizabeth Rosser,Pam Tyers,Soverin Karmiol,Stephen B. Dunnett +7 more
TL;DR: Results show that expanded populations of human CNS progenitor cells maintained in a proliferative state in culture can migrate and differentiate into both neurons and astrocytes following intracerebral grafting, and may have potential for development as an alternative source of tissue for neural transplantation in degenerative diseases.
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Evidence for specific cognitive deficits in preclinical Huntington's disease.
Andrew D. Lawrence,John R. Hodges,Anne Elizabeth Rosser,Ann Kershaw,Charles ffrench-Constant,David C. Rubinsztein,Trevor W. Robbins,Barbara J. Sahakian +7 more
TL;DR: It is suggested that these cognitive impairments relate to a common deficit in inhibitory control mechanisms, under the control of striatofrontal mechanisms, and that such a deficit is present in Huntington's disease mutation carriers prior to the onset of definite motor symptomatology.
Journal ArticleDOI
Executive and mnemonic functions in early Huntington's disease
Andrew D. Lawrence,Barbara J. Sahakian,John R. Hodges,Anne Elizabeth Rosser,Klaus W. Lange,Trevor W. Robbins +5 more
TL;DR: Patients with early Huntington's disease were found to have a wide range of cognitive impairments encompassing both visuospatial memory and executive functions, a pattern distinct from those seen in other basal ganglia disorders.
Journal ArticleDOI
Targeting Huntingtin Expression in Patients with Huntington’s Disease
Sarah J. Tabrizi,Blair R. Leavitt,G. Bernhard Landwehrmeyer,Edward J. Wild,Carsten Saft,Roger A. Barker,Nick F. Blair,D Craufurd,Josef Priller,Hugh Rickards,Anne Elizabeth Rosser,Holly B. Kordasiewicz,Christian Czech,Eric E. Swayze,Daniel A. Norris,Tiffany L. Baumann,Irene Gerlach,Scott Schobel,Erika Paz,Anne Smith,C. Frank Bennett,Roger M. Lane +21 more
TL;DR: Intrathecal administration of HTTRx to patients with early Huntington's disease was not accompanied by serious adverse events and dose-dependent reductions in concentrations of mutant huntingtin were observed.