R
Roger A. Barker
Researcher at University of Cambridge
Publications - 29
Citations - 1182
Roger A. Barker is an academic researcher from University of Cambridge. The author has contributed to research in topics: Parkinson's disease & Huntington's disease. The author has an hindex of 10, co-authored 29 publications receiving 958 citations. Previous affiliations of Roger A. Barker include Harvard University & Lund University.
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Journal ArticleDOI
Targeting Huntingtin Expression in Patients with Huntington’s Disease
Sarah J. Tabrizi,Blair R. Leavitt,G. Bernhard Landwehrmeyer,Edward J. Wild,Carsten Saft,Roger A. Barker,Nick F. Blair,D Craufurd,Josef Priller,Hugh Rickards,Anne Elizabeth Rosser,Holly B. Kordasiewicz,Christian Czech,Eric E. Swayze,Daniel A. Norris,Tiffany L. Baumann,Irene Gerlach,Scott Schobel,Erika Paz,Anne Smith,C. Frank Bennett,Roger M. Lane +21 more
TL;DR: Intrathecal administration of HTTRx to patients with early Huntington's disease was not accompanied by serious adverse events and dose-dependent reductions in concentrations of mutant huntingtin were observed.
Journal ArticleDOI
Inhibition of subliminally primed responses is mediated by the caudate and thalamus : evidence from functional MRI and Huntington's disease
Adam R. Aron,Friederike Schlaghecken,Paul C. Fletcher,Edward T. Bullmore,Martin Eimer,Roger A. Barker,Barbara J. Sahakian,Trevor W. Robbins +7 more
TL;DR: The finding that Huntington's disease patients with greater chorea were disinhibited is consistent with the theory that chorea arises from selective degeneration of striatal projections to the lateral globus pallidus, while the exaggerated inhibitory effect for patients with little or no chorea may be due to additional degeneration to the medial globus Pallidus.
Journal ArticleDOI
Prediction of cognition in Parkinson's disease with a clinical-genetic score : a longitudinal analysis of nine cohorts
Ganqiang Liu,Joseph J. Locascio,Joseph J. Locascio,Jean-Christophe Corvol,Brendon P. Boot,Brendon P. Boot,Zhixiang Liao,Kara Page,Kara Page,Daly Franco,Daly Franco,Kyle Burke,Kyle Burke,Iris E. Jansen,Iris E. Jansen,Ana Trisini-Lipsanopoulos,Ana Trisini-Lipsanopoulos,Sophie Winder-Rhodes,Caroline M. Tanner,Anthony E. Lang,Shirley Eberly,Alexis Elbaz,Alexis Brice,Graziella Mangone,Bernard Ravina,Ira Shoulson,Florence Cormier-Dequaire,Peter Heutink,Peter Heutink,Jacobus J. van Hilten,Roger A. Barker,Caroline H. Williams-Gray,Johan Marinus,Clemens R Scherzer,Bradley T. Hyman,Adrian J. Ivinson,Lewis Sudarsky,Michael T. Hayes,Chizoba C. Umeh,Reisa A. Sperling,John H. Growdon,Michael A. Schwarzschild,Albert Y. Hung,Alice W. Flaherty,Deborah Blacker,Anne-Marie Wills,U. Shivraj Sohur,Nicte I. Mejia,Anand Viswanathan,Stephen N. Gomperts,Vikram Khurana,Mark W. Albers,Maria Alora-Palli,Scott M. McGinnis,Nutan Sharma,Bradford C. Dickerson,Matthew P. Frosch,Teresa Gomez-Isla,Steven M. Greenberg,James F. Gusella,Trey Hedden,E. Tessa Hedley-Whyte,Aaron M. Koenig,Marta Marquis-Sayagues,Gad A. Marshall,Olivia I. Okereke,Anat Stemmer-Rachaminov,Jessica Kloppenburg,Michael G. Schlossmacher,Dennis J. Selkoe,Thomas Yi,Haining Li,Gabriel Stalberg,Roger A. Barker,Thomas Foltynie,CH Williams-Gray,Trevor W. Robbins,Carol Brayne,Sarah L Mason,David P. Breen,Gemma Cummins,J.M. Evans,Alain Mallet,Marie Vidailhet,Anne-Marie Bonnet,Cecilia Bonnet,David Grabli,Andreas Hartmann,Stephan Klebe,Lucette Lacomblez,Frédéric Bourdain,Jean-Philippe Brandel,Pascal Derkinderen,Franck Durif,Valérie Mesnage,Fernando Pico,Olivier Rascol,Christine Brefel-Courbon,Fabienne Ory-Magne,Sylvie Forlani,Suzanne Lesage,Khadija Tahiri,Roger L. Albin,Roy N. Alcalay,Alberto Ascherio,Dubois Bowman,Alice Chen-Plotkin,Ted M. Dawson,Richard B. Dewey,Dwight C. German,Rachel Saunders-Pullman,Clemens R. Scherzer,David E. Vaillancourt,Vladislav A. Petyuk,Andrew B. West,Jing Zhang +115 more
TL;DR: A prediction algorithm for global cognitive impairment (defined as Mini Mental State Examination ≤25) using data from nine cohorts of patients with Parkinson's disease from North America and Europe assessed between 1986 and 2016 is built.
Journal ArticleDOI
UCHL-1 is not a Parkinson's disease susceptibility gene
Daniel G. Healy,Patrick M. Abou-Sleiman,Juan P. Casas,Kourosh R. Ahmadi,Timothy Lynch,Sonia Gandhi,Miratul M. K. Muqit,Thomas Foltynie,Roger A. Barker,Kailash P. Bhatia,Niall Quinn,A J Lees,A J Lees,J. M. Gibson,Janice L. Holton,Tamas Revesz,David Goldstein,Nicholas W. Wood +17 more
TL;DR: In a large case-control study in white individuals (3,023 subjects), the S18Y variant was not protective against Parkinson's disease under any genetic model of inheritance, and a cumulative meta-analysis showed a trend toward a null effect.
Journal ArticleDOI
Genetic risk of Parkinson disease and progression:: An analysis of 13 longitudinal cohorts
Hirotaka Iwaki,Cornelis Blauwendraat,Hampton L. Leonard,Ganqiang Liu,Jodi Maple-Grødem,Jean-Christophe Corvol,Lasse Pihlstrøm,Marlies van Nimwegen,Samantha J. Hutten,Khanh-Dung H. Nguyen,Jacqueline Rick,Shirley Eberly,Faraz Faghri,Peggy Auinger,Kirsten M. Scott,Ruwani Wijeyekoon,Vivianna M. van Deerlin,Dena G. Hernandez,Aaron G. Day-Williams,Alexis Brice,Guido Alves,Alastair J. Noyce,Ole-Bjørn Tysnes,Jonathan R. Evans,David P. Breen,Karol Estrada,Claire E. Wegel,Fabrice Danjou,David Simon,Bernard Ravina,Mathias Toft,Peter Heutink,Bastiaan R. Bloem,Daniel Weintraub,Roger A. Barker,Caroline H. Williams-Gray,Bart P.C. van de Warrenburg,Jacobus J. van Hilten,Clemens R. Scherzer,Andrew B. Singleton,Mike A. Nalls +40 more
TL;DR: Evidence is provided that alleles associated with Parkinson disease risk, in particular GBA variants, also contribute to the heterogeneity of multiple motor and nonmotor aspects.