A
Anne Köhler
Researcher at Max Planck Society
Publications - 15
Citations - 1290
Anne Köhler is an academic researcher from Max Planck Society. The author has contributed to research in topics: T cell & CD8. The author has an hindex of 14, co-authored 15 publications receiving 1262 citations.
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Journal ArticleDOI
Poor correlation between BCG vaccination-induced T cell responses and protection against tuberculosis
Hans-Willi Mittrücker,Ulrich Steinhoff,Anne Köhler,Marion Krause,Doris Lazar,Peggy Mex,Delia Miekley,Stefan H. E. Kaufmann +7 more
TL;DR: The data question the measurement of IFN-γ secretion by CD4+ T cells and emphasize the need for new biomarkers for evaluation of tuberculosis vaccine efficacies.
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Regulatory CD4+CD25+ T cells restrict memory CD8+ T cell responses.
Mischo Kursar,Kerstin Bonhagen,Joachim Fensterle,Anne Köhler,Robert Hurwitz,Thomas Kamradt,Stefan H. E. Kaufmann,Hans-Willi Mittrücker +7 more
TL;DR: It is demonstrated that CD4+ T cells control the CD8+ T cell response in two directions: Initially, they promote the generation of a CD8- T cell responses and later they restrain the strength of theCD8-T cell memory response.
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Cutting Edge: Role of B Lymphocytes in Protective Immunity Against Salmonella typhimurium Infection
TL;DR: B cell-mediated immunity plays a distinct role in control of S. typhimurium in susceptible mice by infecting mice on a susceptible background and deficient in B cells with different strains of the bacterium, and this work could for the first time formally clarify the role of B cells in the response against S.Typhi.
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Characterization of the Murine T-Lymphocyte Response to Salmonella enterica Serovar Typhimurium Infection
TL;DR: Although an unexpectedly large population of both CD4+ and CD8+ T cells is activated and acquires the potential to secrete IFN-γ, this activation is not paralleled by substantial expansion of these T-cell populations.
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Role of CD28 for the Generation and Expansion of Antigen-Specific CD8+ T Lymphocytes During Infection with Listeria monocytogenes
TL;DR: Participation of CD28 signaling in the generation and expansion of Ag-specific CD8+ T cells in listeriosis is demonstrated, however, Ag- specific CD8 + T cells generated in the absence ofCD28 differentiated into normal effector and memory T cells.