H
Hans-Willi Mittrücker
Researcher at University of Hamburg
Publications - 125
Citations - 9746
Hans-Willi Mittrücker is an academic researcher from University of Hamburg. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 49, co-authored 115 publications receiving 8786 citations. Previous affiliations of Hans-Willi Mittrücker include Eppendorf (Germany) & Max Planck Society.
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Journal ArticleDOI
Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function
Hans-Willi Mittrücker,Toshifumi Matsuyama,Alex Grossman,Thomas M. Kündig,Julia Potter,Arda Shahinian,Andrew Wakeham,Bruce Patterson,Pamela S. Ohashi,Tak W. Mak +9 more
TL;DR: Lymphocyte-specific interferon regulatory factor (LSIRF) (now called IRF4) is a transcription factor expressed only in lymphocytes that is essential for the function and homeostasis of both mature B and mature T lymphocytes.
Journal ArticleDOI
Regulation of T Cell Receptor Signaling by Tyrosine Phosphatase SYP Association with CTLA-4
Luc E. M. Marengere,Paul Waterhouse,Gordon S. Duncan,Hans-Willi Mittrücker,Gen-Sheng Feng,Tak W. Mak +5 more
TL;DR: The absence of CTLA-4 results in uncontrolled T cell proliferation and the T cell receptor-specific kinases FYN, LCK, and ZAP-70 as well as the RAS pathway were found to be activated in T cells of Ctla-4−/− mutant mice.
Journal ArticleDOI
MSH2 deficient mice are viable and susceptible to lymphoid tumours.
Armin Reitmair,Rudolf Schmits,A. Ewel,Bharati Bapat,Mark Redston,Angela Mitri,Paul Waterhouse,Hans-Willi Mittrücker,Andrew Wakeham,B. Liu,A. Thomason,Henrik Griesser,Steve Gallinger,W.G. Ballhausen,Richard Fishel,T. W. Mak +15 more
TL;DR: A direct link between MSH2 deficiency and the pathogenesis of cancer is established and these mutant mice should be good models to study the progression of tumours and also to screen carcinogenic and anti–cancer agents.
Journal ArticleDOI
Duration of TCR stimulation determines costimulatory requirement of T cells.
Thomas M. Kündig,Arda Shahinian,Kazuhiro Kawai,Hans-Willi Mittrücker,Eric Sebzda,Martin F. Bachmann,Tak W. Mak,Tak W. Mak,Pamela S. Ohashi +8 more
TL;DR: Using mice deficient for an important costimulatory molecule, CD28, it is shown that a transient signal-1 alone, either through infection with an abortively replicating virus, or through injection of viral peptide, anergizes CD8+ T cells, demonstrating the biological relevance of T cell anergy in vivo.
Journal ArticleDOI
Immune response to infection with Salmonella typhimurium in mice.
TL;DR: The response to S. typhimurium involves both T and B cell‐mediated immunity, and mechanisms mediated by both lymphocyte populations are important for control of primary infection and protection against secondary infection.