A
Anne-Laure Joly
Researcher at French Institute of Health and Medical Research
Publications - 10
Citations - 682
Anne-Laure Joly is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Heat shock protein & Medicine. The author has an hindex of 7, co-authored 7 publications receiving 626 citations. Previous affiliations of Anne-Laure Joly include University of Burgundy.
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Journal ArticleDOI
Dual role of heat shock proteins as regulators of apoptosis and innate immunity.
TL;DR: The roles of HSP70 and HSP90 in apoptosis and in innate immunity and how these functions are being exploited in cancer therapy are focused on.
Journal ArticleDOI
Anti-cancer therapeutic approaches based on intracellular and extracellular heat shock proteins.
Celine Didelot,David Lanneau,Mathilde Brunet,Anne-Laure Joly,Aurélie de Thonel,Gabriela Chiosis,Carmen Garrido +6 more
TL;DR: This review will discuss this different and often paradoxical approaches in cancer therapy based on the dual role of Hsps, protective/tumorigenic versus immunogenic.
Journal ArticleDOI
Extracellular HSP27 mediates angiogenesis through Toll-like receptor 3
Dominique Thuringer,Gaëtan Jego,Gaëtan Jego,Guillaume Wettstein,Olivier Terrier,Laurent Cronier,Nadhir Yousfi,Sophie Hébrard,André Bouchot,Adonis Hazoumé,Anne-Laure Joly,Martin E. Gleave,Manuel Rosa-Calatrava,Eric Solary,Carmen Garrido,Carmen Garrido +15 more
TL;DR: It is shown that extracellular HSP27 has a proangiogenic effect evidenced on chick chorioallantoic membrane, which mediates angiogenesis through Toll‐like receptor 3.
Journal ArticleDOI
Heat shock protein 27 is involved in SUMO-2/3 modification of heat shock factor 1 and thereby modulates the transcription factor activity.
M Brunet Simioni,A de Thonel,A de Thonel,Arlette Hammann,Arlette Hammann,Anne-Laure Joly,Anne-Laure Joly,Guillaume Bossis,Guillaume Bossis,Eric Fourmaux,A Bouchot,Jacques Landry,Marc Piechaczyk,Marc Piechaczyk,Carmen Garrido,Carmen Garrido +15 more
TL;DR: The data show that HSP27 exerts a feedback inhibition of HSF1 transactivation and enlighten the strictly regulated interplay between HSPs and HSF2, raising the possibility that H SP27 may act as asumO-E3 ligase specific for SUMO-2/3.
Journal ArticleDOI
Heat shock proteins as danger signals for cancer detection
Renaud Seigneuric,Hajare Mjahed,Hajare Mjahed,Jessica Gobbo,Jessica Gobbo,Anne-Laure Joly,Anne-Laure Joly,Kevin Berthenet,Kevin Berthenet,Sarah Shirley,Carmen Garrido,Carmen Garrido +11 more
TL;DR: A survey of recent literature highlights some recurring weaknesses in studies of the HSPs, but also identifies findings that indicate that some H SPs have potential as cancer biomarkers for successful clinical applications.