Anne Louise Sørensen

TL;DR: Chemoenzymatic synthesis of extended MUC1 TR glycopeptides with cancer-associated O-glycosylation using a panel of recombinant human glycosyltransferases is developed and a MAb with similar specificity as the elicited immune response was generated and shown to have the same remarkable cancer specificity.

TL;DR: The study demonstrates that the GSTA region of the MUC1 tandem repeat contains a highly immunodominant epitope when presented with immature short O-glycans, which makes it a prime candidate for immunodiagnostic and therapeutic measures.

TL;DR: This article showed that platelet GPIbα is a major counterreceptor on ST3Gal-IV−/− platelets for asialoglycoprotein receptors, which results in accelerated platelet clearance by asial glycoprotein receptor-expressing scavenger cells, a mechanism that was recently shown to induce thrombocytopenia during Streptococcus pneumoniae sepsis.

TL;DR: It is reported here that prolonged refrigeration increased the density and concentration of exposed galactose residues on platelets such that hepatocytes, through Ashwell-Morell receptor binding, become increasingly involved in platelet removal.

TL;DR: In this article, the authors developed a similar glycosylation process by adding UDP-galactose to human apheresis platelets to prevent the rapid clearance of cold-stored platelets.