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Anne S. Kienhuis
Researcher at Centre for Health Protection
Publications - 36
Citations - 984
Anne S. Kienhuis is an academic researcher from Centre for Health Protection. The author has contributed to research in topics: In vivo & Toxicogenomics. The author has an hindex of 18, co-authored 31 publications receiving 846 citations. Previous affiliations of Anne S. Kienhuis include Wageningen University and Research Centre & Maastricht University.
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Journal ArticleDOI
Systems toxicology: applications of toxicogenomics, transcriptomics, proteomics and metabolomics in toxicology
TL;DR: It is argued that in the (near) future, human health risk assessment will truly benefit from toxicogenomics (systems toxicology), and the advantages and limitations of the different technologies are evaluated.
Journal ArticleDOI
Exploring the zebrafish embryo as an alternative model for the evaluation of liver toxicity by histopathology and expression profiling
Marja Driessen,Anne S. Kienhuis,Jeroen L. A. Pennings,Tessa E. Pronk,Evert-Jan van de Brandhof,Marianne Roodbergen,Herman P. Spaink,Bob van de Water,Leo T.M. van der Ven +8 more
TL;DR: Both the use of NGS of pooled RNA extracts analysis combined with histopathology and traditional microarray in single case showed the potential to detect liver-related genes and processes within the transcriptome of a whole zebrafish embryo, supporting the applicability of the whole ZFE model for compound-induced hepatotoxicity screening.
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Assessing the metabolic competence of sandwich-cultured mouse primary hepatocytes.
Karen Mathijs,Anne S. Kienhuis,Karen Brauers,Danyel Jennen,Agustín Lahoz,Jos C. S. Kleinjans,Joost H.M. van Delft +6 more
TL;DR: Results indicate that the sandwich-cultured primary mouse hepatocytes system is robust and seems to maintain its metabolic competence better than that of the rat hepatocyte system.
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A transcriptomics-based hepatotoxicity comparison between the zebrafish embryo and established human and rodent in vitro and in vivo models using cyclosporine A, amiodarone and acetaminophen
Marja Driessen,Marja Driessen,Alexa P. Vitins,Jeroen L. A. Pennings,Anne S. Kienhuis,Bob van de Water,Leo T.M. van der Ven +6 more
TL;DR: The zebrafish embryo (ZFE) model is at least as comparable to traditional models in identifying hepatotoxic activity and has the potential for use as a pre-screen to determine the hepatot toxic potential of compounds.
Journal ArticleDOI
Parallelogram approach using rat-human in vitro and rat in vivo toxicogenomics predicts acetaminophen-induced hepatotoxicity in humans.
Anne S. Kienhuis,Marcel C. G. van de Poll,Heleen M. Wortelboer,Marcel H. M. van Herwijnen,Ralph W.H. Gottschalk,Cornelis H. C. Dejong,André Boorsma,Richard S. Paules,Jos C. S. Kleinjans,Rob H. Stierum,Joost H.M. van Delft +10 more
TL;DR: This study is the first that used a toxicogenomics-based parallelogram approach, extrapolating in vitro to in vivo and interspecies, to reveal relevant mechanisms indicative of APAP-induced liver toxicity in humans in vivo.