Jeroen L. A. Pennings

TL;DR: The findings establish the Ercc1∆/− mouse as a powerful model organism for health-sustaining interventions, reveal potential for reducing endogenous DNA damage, facilitate a better understanding of the molecular mechanism of dietary restriction and suggest a role for counterintuitive dietary-restriction-like therapy for human progeroid genome instability syndromes and possibly neurodegeneration in general.

TL;DR: This study provides the first experimental proof that CRD increases breast cancer development, and suggests internal desynchronization and sleep disturbance as mechanisms linking shift work with cancer development and obesity.

TL;DR: Experiments involving Lactobacillus casei Shirota (LcS) detected mainly enhancement of innate immune responses and promotion of Th1 mediated immune reactivity, which indicates that beneficial as well as harmful effects on immune related disorders could occur after LcS consumption.

TL;DR: Comparison of corticogenesis, gene expression and behavior in three mouse models of Down syndrome revealed major differences between the models as well as significant limitations in each strain for understanding neurobiological changes in the human phenotype.

TL;DR: In conclusion, KC expression profiling can identify contact sensitizers, providing opportunities for nonanimal testing for sensitizing potential and suggesting that contact Sensitizers induce the oxidative stress pathway in KC.