Anne Z. Murphy

TL;DR: In this article, members of the Sex, Gender and Pain Special Interest Group of the International Association for the Study of Pain met to discuss the following: (1) what is known about sex and gender differences in pain and analgesia; (2) what are the "best practice" guidelines for pain research with respect to sex this article.

TL;DR: It is shown for the first time that extracellular concentrations of oxytocin are increased in the nucleus accumbens of female prairie vole during unrestricted interactions with a male, and it is shown that the distribution of Oxytocin-immunoreactive fibers in the cluster is conserved in voles, mice and rats, despite remarkable species differences in oxytocIn receptor binding in the region.

TL;DR: For over half a century, male rodents have been the default model organism in preclinical neuroscience research, a convention that has likely contributed to higher rates of misdiagnosis and adverse side effects from drug treatment in women as mentioned in this paper.

TL;DR: Compared OTR and V1aR binding in adjacent brain sections and also with markers that delineate neuroanatomical boundaries in the ventral forebrain, potential neural mechanisms by which receptors in these brain regions mediate pair bond formation in this monogamous prairie vole are discussed.

TL;DR: It is reported that males had a significantly higher expression of MOR in the ventrolateral PAG compared with cycling females, whereas the lowest level of expression was observed in proestrus females, and selective lesions of MOR-expressing neurons in the vents resulted in a significant reduction in the effects of systemic morphine in males only.