A
Annemieke J.M. de Ruijter
Researcher at University of Amsterdam
Publications - 5
Citations - 2945
Annemieke J.M. de Ruijter is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Histone deacetylase inhibitor & Trichostatin A. The author has an hindex of 5, co-authored 5 publications receiving 2740 citations.
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Journal ArticleDOI
Histone deacetylases (HDACs): characterization of the classical HDAC family
Annemieke J.M. de Ruijter,Albert H. van Gennip,Huib N. Caron,Stephan Kemp,André B.P. van Kuilenburg +4 more
TL;DR: In this paper, a comprehensive overview of the structure, function and tissue distribution of members of the classical histone deacetylase (HDAC) family, in order to gain insight into the regulation of gene expression through HDAC activity is presented.
Journal ArticleDOI
Gene expression profiling in response to the histone deacetylase inhibitor BL1521 in neuroblastoma
Annemieke J.M. de Ruijter,Rutger Meinsma,Peter Bosma,Stephan Kemp,Huib N. Caron,André B.P. van Kuilenburg +5 more
TL;DR: Several genes in the Wnt and the Delta/Notch pathways were changed in response toBL1521 treatment, suggesting that BL1521 is able to induce the differentiation of neuroblastoma cells into a more mature phenotype.
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The novel histone deacetylase inhibitor BL1521 inhibits proliferation and induces apoptosis in neuroblastoma cells
Annemieke J.M. de Ruijter,Stephan Kemp,Gert Jan Kramer,Rutger Meinsma,Judith O. Kaufmann,Huib N. Caron,André B.P. van Kuilenburg +6 more
TL;DR: The results show that BL1521 is a potent inhibitor of HDAC and that HDACs are an attractive target for selective chemotherapy in neuroblastoma.
Journal ArticleDOI
Histone deacetylase inhibitor BL1521 induces a G1-phase arrest in neuroblastoma cells through altered expression of cell cycle proteins
Krista Ouwehand,Annemieke J.M. de Ruijter,Chris van Bree,Huib N. Caron,André B.P. van Kuilenburg +4 more
TL;DR: The effect of BL1521, a novel HDACi, on the cell cycle distribution and the induction of apoptosis was investigated in a panel of MYCN single copy and MYCN amplified neuroblastoma cell lines, indicating a possible mechanism for the cell‐cycle arrest.
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Antagonistic effects of sequential administration of BL1521, a histone deacetylase inhibitor, and gemcitabine to neuroblastoma cells
TL;DR: Cancer cells that respond to HDACi with a cell cycle arrest and differentiation may no longer be sensitive to dFdC, and no difference in the deoxycytidine kinase activity was observed in response to BL1521.