A
Annette M.G. Dirac
Researcher at Netherlands Cancer Institute
Publications - 19
Citations - 5009
Annette M.G. Dirac is an academic researcher from Netherlands Cancer Institute. The author has contributed to research in topics: Ubiquitin & Deubiquitinating enzyme. The author has an hindex of 16, co-authored 19 publications receiving 4672 citations. Previous affiliations of Annette M.G. Dirac include University of Cambridge & University of Amsterdam.
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Journal ArticleDOI
A Genomic and Functional Inventory of Deubiquitinating Enzymes
Sebastian M.B. Nijman,Mark P.A. Luna-Vargas,Arno Velds,Thijn R. Brummelkamp,Annette M.G. Dirac,Titia K. Sixma,René Bernards +6 more
TL;DR: An inventory of the deubiquitinating enzymes encoded in the human genome is presented and the literature concerning these enzymes is reviewed, with particular emphasis on their function, specificity, and the regulation of their activity.
Journal ArticleDOI
Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB
TL;DR: It is reported here that inhibition of one of these enzymes, the familial cylindromatosis tumour suppressor gene (CYLD), having no known function, enhances activation of the transcription factor NF-κB, and this effect can be relieved by aspirin derivatives that inhibit NF-σB activity.
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The Deubiquitinating Enzyme USP1 Regulates the Fanconi Anemia Pathway
Sebastian M.B. Nijman,Tony T. Huang,Annette M.G. Dirac,Thijn R. Brummelkamp,Ron M. Kerkhoven,Alan D. D'Andrea,René Bernards +6 more
TL;DR: It is proposed that USP1 deubiquitinates FANCD2 when cells exit S phase or recommence cycling after a DNA damage insult and may play a critical role in the FA pathway by recycling FAN CD2.
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Elongator, a multisubunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation.
Gabriel Otero,Jane Fellows,Yang Li,Therese de Bizemont,Annette M.G. Dirac,Claes M. Gustafsson,Hediye Erdjument-Bromage,Paul Tempst,Jesper Q. Svejstrup +8 more
TL;DR: Phenotypes of yeast elp1 delta cells demonstrated an involvement of elongator in transcriptional elongation as well as activation in vivo, and data indicate that the transition from transcriptional initiation to elongation involves an exchange of the multiprotein mediator complex for elongators in a reaction coupled to CTD hyperphosphorylation.
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USP15 stabilizes TGF-β receptor I and promotes oncogenesis through the activation of TGF-β signaling in glioblastoma
Pieter Johan Adam Eichhorn,Laura Rodon,Alba Gonzalez-Junca,Annette M.G. Dirac,Magui Gili,Elena Martínez-Sáez,Claudia Aura,Ignasi Barba,Vicente Peg,Aleix Prat,Aleix Prat,Isabel Cuartas,Jose Jimenez,David Garcia-Dorado,Juan Sahuquillo,René Bernards,José Baselga,José Baselga,José Baselga,Joan Seoane,Joan Seoane,Joan Seoane +21 more
TL;DR: Results show that USP15 regulates the TGF-β pathway and is a key factor in glioblastoma pathogenesis, and depletion of USP 15 decreases the oncogenic capacity of patient-derived glioma-initiating cells due to the repression of T GF-β signaling.