C
Claes M. Gustafsson
Researcher at University of Gothenburg
Publications - 130
Citations - 13087
Claes M. Gustafsson is an academic researcher from University of Gothenburg. The author has contributed to research in topics: RNA polymerase II & Mitochondrial DNA. The author has an hindex of 58, co-authored 123 publications receiving 11564 citations. Previous affiliations of Claes M. Gustafsson include Karolinska Institutet & University of Toronto.
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Journal ArticleDOI
Mitochondrial transcription factor A regulates mtDNA copy number in mammals
Mats I. Ekstrand,Maria Falkenberg,Anja Rantanen,Chan Bae Park,Martina Gaspari,Kjell Hultenby,Pierre Rustin,Claes M. Gustafsson,Nils-Göran Larsson +8 more
TL;DR: Genetic evidence for a novel role for TFAM in direct regulation of mt DNA copy number in mammals is provided and it is demonstrated that mtDNA copy number is directly proportional to the total TFAM protein levels also in mouse embryos.
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DNA Replication and Transcription in Mammalian Mitochondria
TL;DR: The mitochondrion was originally a free-living prokaryotic organism, which explains the presence of a compact mammalian mitochondrial DNA in contemporary mammalian cells, and the proposition that some genes required for DNA replication and transcription were acquired together from a phage early in the evolution of the eukaryotic cell.
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Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA
Maria Falkenberg,Martina Gaspari,Anja Rantanen,Aleksandra Trifunovic,Nils-Göran Larsson,Claes M. Gustafsson +5 more
TL;DR: The presence of two proteins that interact with mammalian POLRMT may allow flexible regulation of mtDNA gene expression in response to the complex physiological demands of mammalian metabolism.
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MEG3 long noncoding RNA regulates the TGF-β pathway genes through formation of RNA–DNA triplex structures
Tanmoy Mondal,Santhilal Subhash,Roshan Vaid,Stefan Enroth,Sireesha Uday,Björn Reinius,Sanhita Mitra,Arif Mohammed,Alva Rani James,Emily Hoberg,Aristidis Moustakas,Ulf Gyllensten,Steven J.M. Jones,Claes M. Gustafsson,Andrew H. Sims,Fredrik Westerlund,Eduardo Gorab,Chandrasekhar Kanduri +17 more
TL;DR: It is shown that MEG3 and EZH2 share common target genes, including the TGF-β pathway genes, and RNA–DNA triplex formation could be a general characteristic of target gene recognition by the chromatin-interacting lncRNAs.
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Elongator, a multisubunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation.
Gabriel Otero,Jane Fellows,Yang Li,Therese de Bizemont,Annette M.G. Dirac,Claes M. Gustafsson,Hediye Erdjument-Bromage,Paul Tempst,Jesper Q. Svejstrup +8 more
TL;DR: Phenotypes of yeast elp1 delta cells demonstrated an involvement of elongator in transcriptional elongation as well as activation in vivo, and data indicate that the transition from transcriptional initiation to elongation involves an exchange of the multiprotein mediator complex for elongators in a reaction coupled to CTD hyperphosphorylation.