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Annie L'Helgoualc'h
Researcher at University of Rennes
Publications - 24
Citations - 1479
Annie L'Helgoualc'h is an academic researcher from University of Rennes. The author has contributed to research in topics: Hepatic stellate cell & Interleukin 33. The author has an hindex of 20, co-authored 24 publications receiving 1371 citations. Previous affiliations of Annie L'Helgoualc'h include French Institute of Health and Medical Research.
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Journal ArticleDOI
Interleukin-33 overexpression is associated with liver fibrosis in mice and humans.
Pierrick Marvie,Mariette Lisbonne,Annie L'Helgoualc'h,Michel Rauch,Bruno Turlin,Laurence Preisser,Katia Bourd-Boittin,Nathalie Théret,Hugues Gascan,Claire Piquet-Pellorce,Michel Samson +10 more
TL;DR: IL‐33 is strongly associated with fibrosis in chronic liver injury and activated HSC are a source of IL‐33, which was increased in cultured HSC when stimulated by pro‐inflammatory cytokines.
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Erk5 controls Slug expression and keratinocyte activation during wound healing.
TL;DR: A novel EGFR/Erk5/Slug pathway is implicate in the control of cytoskeleton organization and cell motility in keratinocytes treated with EGF and shows altered morphology and ability to form cell aggregates during cutaneous wound healing.
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Infection with Influenza Virus Induces IL-33 in Murine Lungs
Ronan Le Goffic,Muhammad Imran Arshad,Michel Rauch,Annie L'Helgoualc'h,Bernard Delmas,Claire Piquet-Pellorce,Michel Samson +6 more
TL;DR: A profound overexpression of IL-33 protein was evident in IAV-infected murine lungs and bronchoalveolar lavages of influenza- infected mice, compared with low concentrations in naive lungs in vivo, suggesting a role for IL- 33 in virus-induced lung infections.
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The disintegrin and metalloproteinase ADAM12 contributes to TGF-beta signaling through interaction with the type II receptor.
Azeddine Atfi,Emmanuelle Dumont,Frédéric Colland,Dominique Bonnier,Annie L'Helgoualc'h,Céline Prunier,Nathalie Ferrand,Bruno Clément,Ulla M. Wewer,Nathalie Théret +9 more
TL;DR: ADAM12 is defined as a new partner of TbetaRII that facilitates its trafficking to early endosomes in which activation of the Smad pathway is initiated.
Journal Article
Activation of matrix metalloproteinase-2 from hepatic stellate cells requires interactions with hepatocytes.
TL;DR: The role of cell-cell cooperation in the activation of pro-MMP-2 in the liver is investigated, using pure cultures and co-cultures of hepatocytes and hepatic stellate cells (HSCs), and data show that the co-expression of TIMP-2, MMP- 2, and MT-M MP-1 by HSCs does not lead to secretion of the activated form of M MP-2.