R
Ronan Le Goffic
Researcher at Université Paris-Saclay
Publications - 57
Citations - 3726
Ronan Le Goffic is an academic researcher from Université Paris-Saclay. The author has contributed to research in topics: Influenza A virus & Virus. The author has an hindex of 23, co-authored 54 publications receiving 3057 citations. Previous affiliations of Ronan Le Goffic include University of Rennes & Pasteur Institute.
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Journal ArticleDOI
Involvement of Toll-like Receptor 3 in the Immune Response of Lung Epithelial Cells to Double-stranded RNA and Influenza A Virus *
Loïc Guillot,Ronan Le Goffic,Sarah Bloch,Nicolas Escriou,Shizuo Akira,Michel Chignard,Mustapha Si-Tahar +6 more
TL;DR: It is demonstrated that TLR3 contributes directly to the immune response of respiratory epithelial cells to influenza A virus and dsRNA, and a molecular mechanism by which these stimuli induce epithelial cell activation is proposed.
Journal ArticleDOI
Detrimental contribution of the Toll-like receptor (TLR)3 to influenza A virus-induced acute pneumonia.
Ronan Le Goffic,Ronan Le Goffic,Viviane Balloy,Viviane Balloy,Micheline Lagranderie,Lena Alexopoulou,Lena Alexopoulou,Nicolas Escriou,Richard A. Flavell,Richard A. Flavell,Michel Chignard,Michel Chignard,Mustapha Si-Tahar,Mustapha Si-Tahar +13 more
TL;DR: These findings show for the first time that TLR3-IAV interaction critically contributes to the debilitating effects of a detrimental host inflammatory response.
Journal ArticleDOI
Cutting Edge: Influenza A virus activates TLR3-dependent inflammatory and RIG-I-dependent antiviral responses in human lung epithelial cells.
Ronan Le Goffic,Ronan Le Goffic,Julien Pothlichet,Julien Pothlichet,Damien Vitour,Takashi Fujita,Eliane F. Meurs,Michel Chignard,Michel Chignard,Mustapha Si-Tahar,Mustapha Si-Tahar +10 more
TL;DR: It is demonstrated that the sensing of IAV by TLR3 primarily regulates a proinflammatory response, whereas RIG-I (but not MDA-5) mediates both a type I IFN-dependent antiviral signaling and a pro inflammatory response.
Journal ArticleDOI
Broad-spectrum non-toxic antiviral nanoparticles with a virucidal inhibition mechanism
Valeria Cagno,Patrizia Andreozzi,Marco D'Alicarnasso,Paulo Jacob Silva,Marie Mueller,Marie Galloux,Ronan Le Goffic,Samuel T. Jones,Samuel T. Jones,Marta Vallino,Jan Hodek,Jan Weber,Soumyo Sen,Emma Rose Janecek,Ahmet Bekdemir,Barbara Sanavio,Chiara Martinelli,Manuela Donalisio,Marie Anne Rameix Welti,Jean-François Eléouët,Yanxiao Han,Laurent Kaiser,Lela Vuković,Caroline Tapparel,Petr Král,Silke Krol,David Lembo,Francesco Stellacci +27 more
TL;DR: These particles show no cytotoxicity, and in vitro nanomolar irreversible activity against herpes simplex virus, human papilloma virus, respiratory syncytial virus, dengue and lenti virus, and are active ex vivo in human cervicovaginal histocultures infected by HSV-2 and in vivo in mice infected with RSV.
Journal ArticleDOI
Massive transient damage of the olfactory epithelium associated with infection of sustentacular cells by SARS-CoV-2 in golden Syrian hamsters.
Bertrand Bryche,Audrey St Albin,Séverine Murri,Sandra Lacôte,Coralie Pulido,Meriadeg Ar Gouilh,Sandrine Lesellier,Alexandre Servat,Marine Wasniewski,Evelyne Picard-Meyer,Elodie Monchatre-Leroy,Romain Volmer,Olivier Rampin,Ronan Le Goffic,Philippe Marianneau,Nicolas Meunier +15 more
TL;DR: Anosmia observed in COVID-19 patient is likely to be linked to a massive and fast desquamation of the OE following sustentacular cells infection with SARS-CoV-2 and subsequent recruitment of immune cells in the Oe and lamina propria.