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Anthea Di Rita
Researcher at University of Rome Tor Vergata
Publications - 13
Citations - 369
Anthea Di Rita is an academic researcher from University of Rome Tor Vergata. The author has contributed to research in topics: Mitophagy & Autophagy. The author has an hindex of 7, co-authored 12 publications receiving 232 citations. Previous affiliations of Anthea Di Rita include University of Siena & Boston Children's Hospital.
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Journal ArticleDOI
HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKα.
Anthea Di Rita,Anthea Di Rita,Angelo Peschiaroli,Pasquale Dâ²Acunzo,Daniela Strobbe,Zehan Hu,Jens Gruber,Mads Nygaard,Matteo Lambrughi,Gerry Melino,Elena Papaleo,Jörn Dengjel,Said El Alaoui,Michelangelo Campanella,Michelangelo Campanella,Volker Dötsch,Vladimir V. Rogov,Flavie Strappazzon,Francesco Cecconi,Francesco Cecconi +19 more
TL;DR: It is demonstrated that AMBRA1 regulates mitophagy through a novel pathway, in which HUWE1 and IKKα are key factors, shedding new lights on the regulation of mitochondrial quality control and homoeostasis in mammalian cells.
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AMBRA1-mediated mitophagy counteracts oxidative stress and apoptosis induced by neurotoxicity in human neuroblastoma SH-SY5Y cells
Anthea Di Rita,Anthea Di Rita,Pasquale D’Acunzo,Luca Simula,Silvia Campello,Flavie Strappazzon,Francesco Cecconi,Francesco Cecconi +7 more
TL;DR: The results strongly suggest that AMBRA1 may have promising neuroprotective properties with an important role in limiting ROS-induced dopaminergic cell death, and the utmost potential to prevent PD or other neurodegenerative diseases associated with mitochondrial oxidative stress.
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HUWE1 controls MCL1 stability to unleash AMBRA1-induced mitophagy.
Flavie Strappazzon,Anthea Di Rita,Angelo Peschiaroli,Pier Paolo Leoncini,Franco Locatelli,Gerry Melino,Gerry Melino,Francesco Cecconi,Francesco Cecconi +8 more
TL;DR: MCL1 is defined as an upstream stress-sensitive protein, functional in AMBRA1-mediated mitophagy, and it is demonstrated that MCL1 stability is regulated by the kinase GSK-3β and the E3 Ubiquitin ligase HUWE1 in regulating AMB RA1- mediatedMitophagy.
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Prosurvival AMBRA1 turns into a proapoptotic BH3-like protein during mitochondrial apoptosis.
Flavie Strappazzon,Anthea Di Rita,Valentina Cianfanelli,Melania D'Orazio,Francesca Nazio,Gian Maria Fimia,Francesco Cecconi +6 more
TL;DR: It is reported that the crucial proautophagic factor AMBRA1 can act as a positive mediator of mitochondrial apoptosis and may represent a novel target in development of therapeutic approaches in clinical diseases.
Journal ArticleDOI
Reversible induction of mitophagy by an optogenetic bimodular system.
Pasquale D’Acunzo,Flavie Strappazzon,Ignazio Caruana,Giacomo Meneghetti,Anthea Di Rita,Luca Simula,Luca Simula,Gerrit Weber,Francesca Del Bufalo,Luisa Dalla Valle,Silvia Campello,Franco Locatelli,Franco Locatelli,Francesco Cecconi,Francesco Cecconi +14 more
TL;DR: An optogenetic system for reversible induction of mitophagy is developed and used in cell culture and zebrafish embryos and it is thought it may turn out to be very useful for a wide range of both therapeutic and research applications.