Mads Nygaard

TL;DR: It is demonstrated that AMBRA1 regulates mitophagy through a novel pathway, in which HUWE1 and IKKα are key factors, shedding new lights on the regulation of mitochondrial quality control and homoeostasis in mammalian cells.

TL;DR: A new and efficient method to calculate the hydrodynamic radius of a disordered protein chain from a model of its structural ensemble, which can be used to compare a simulated ensemble of conformations to NMR diffusion measurements.

TL;DR: This work provides the first description of the conformational ensemble of the MZF1 SCAN domain cross-validated against NMR experimental data, which are probes of structure and dynamics on different timescales.

TL;DR: The discovery of an allosteric agonist for a previously unexploited, dynamic pocket in FFAR1 demonstrates both the power of including molecular dynamics in the drug discovery process and that this specific, clinically proven, but difficult, antidiabetes target can be addressed by chemotypes different from existing ligands.

TL;DR: The question of why disorder has evolved to govern signaling of C1CRs is asked by reviewing the literature in combination with new sequence and biophysical analyses of chain properties across the family, and it is uncovered that the C1 CR-ICDs are fully disordered and brimming with SLiMs.