Anthony Ogawa

TL;DR: A binding assay is developed and shown that labeled ezetimibe glucuronide binds specifically to a single site in brush border membranes and to human embryonic kidney 293 cells expressing NPC1L1, which unequivocally establish NPC1 L1 as the direct target of ezETimibe and should facilitate efforts to identify the molecular mechanism of cholesterol transport.

TL;DR: A small molecule that inhibits OMP biogenesis at the cell surface represents a distinct class of antibacterial agents and possesses a second mechanism of action that kills gram-positive organisms.

TL;DR: The synthesis of a series of novel dihdyropyridine diacid glycogen phosphorylase inhibitors is presented and SAR and functional assay data are discussed, along with the effect of a single inhibitor on blood glucose in a diabetic animal model.

TL;DR: The preparation of a series of substituted indoles coupled to six- and seven-membered cyclic lactams is described and their role as human glycogen phosphorylase a inhibitors discussed and the SAR of the indole moiety and lactam ring are presented.

TL;DR: In this paper, the compounds of the Formula (I) as well as pharmaceutically acceptable salts thereof, which are useful for treating aldosterone-mediated diseases, are disclosed.