S
Scott W. Altmann
Researcher at Schering-Plough
Publications - 23
Citations - 4033
Scott W. Altmann is an academic researcher from Schering-Plough. The author has contributed to research in topics: Intestinal cholesterol absorption & Cholesterol absorption inhibitor. The author has an hindex of 16, co-authored 23 publications receiving 3817 citations.
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Journal ArticleDOI
Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption.
Scott W. Altmann,Harry R. Davis,Li-ji Zhu,Xiaorui Yao,Lizbeth M. Hoos,Glen Tetzloff,Sai Prasad N. Iyer,Maureen Maguire,Andrei Golovko,Ming Zeng,Luquan Wang,Nicholas J. Murgolo,Michael P. Graziano +12 more
TL;DR: It is shown that Niemann-Pick C1Like 1(NPC1L1) protein plays a critical role in the absorption of intestinal cholesterol, and resides in an ezetimibe-sensitive pathway responsible for intestinal cholesterol absorption.
Journal ArticleDOI
The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1).
Margarita Garcia-Calvo,JeanMarie Lisnock,Herbert G. Bull,Brian E. Hawes,Duane A. Burnett,Matthew P. Braun,James H. Crona,Harry R. Davis,Dennis C. Dean,Patricia A. Detmers,Michael P. Graziano,Meredith Hughes,D. Euan MacIntyre,Anthony Ogawa,Kim O’Neill,Sai Prasad N Iyer,Diane E. Shevell,Marsha Smith,Yui S. Tang,Amanda M. Makarewicz,Feroze Ujjainwalla,Scott W. Altmann,Kevin T. Chapman,Nancy A. Thornberry +23 more
TL;DR: A binding assay is developed and shown that labeled ezetimibe glucuronide binds specifically to a single site in brush border membranes and to human embryonic kidney 293 cells expressing NPC1L1, which unequivocally establish NPC1 L1 as the direct target of ezETimibe and should facilitate efforts to identify the molecular mechanism of cholesterol transport.
Journal ArticleDOI
Niemann-Pick C1 Like 1 (NPC1L1) Is the Intestinal Phytosterol and Cholesterol Transporter and a Key Modulator of Whole-body Cholesterol Homeostasis
Harry R. Davis,Li-ji Zhu,Lizbeth M. Hoos,Glen Tetzloff,Maureen Maguire,Jianjun Liu,Xiaorui Yao,Sai Prasad N Iyer,My-Hanh Lam,Erik G. Lund,Patricia A. Detmers,Michael P. Graziano,Scott W. Altmann +12 more
TL;DR: NPC1L1 is required for intestinal uptake of both cholesterol and phytosterols and plays a major role in cholesterol homeostasis and may be a useful drug target for the treatment of hypercholesterolemia and sitosterolemia.
Journal ArticleDOI
OB-BP1/Siglec-6. a leptin- and sialic acid-binding protein of the immunoglobulin superfamily.
Neela Patel,Els C. M. Brinkman-Van der Linden,Scott W. Altmann,Kurt Gish,Sriram Balasubramanian,Jackie C. Timans,David O. Peterson,Marcum P. Bell,J. Fernando Bazan,Ajit Varki,Robert A. Kastelein +10 more
TL;DR: The identification of OB-BP1/Siglec-6 as a Siglec family member, coupled with its restricted expression pattern, suggests that it may mediate cell-cell recognition events by interacting with sialylated glycoprotein ligands expressed on specific cell populations.
Journal ArticleDOI
The identification of intestinal scavenger receptor class B, type I (SR-BI) by expression cloning and its role in cholesterol absorption.
Scott W. Altmann,Harry R. Davis,Xiaorui Yao,Maureen Laverty,Douglas S Compton,Li-ji Zhu,James H. Crona,Mary Ann Caplen,Lizbeth M. Hoos,Glen Tetzloff,Tony Priestley,Duane A. Burnett,Catherine D. Strader,Michael P. Graziano +13 more
TL;DR: The binding of ezetimibe to cells expressing SR-B1 and the functional blockade of SR-b1-mediated cholesterol absorption in vitro suggest that SR- B1 plays a role in intestinal cholesterol metabolism and the inhibitory activity of eZetimibes.