Marsha Smith

TL;DR: Nicastrin and presenilins are likely to be functional components of a multimeric complex necessary for the intramembranous proteolysis of proteins such as Notch/GLP-1 and βAPP.

TL;DR: A binding assay is developed and shown that labeled ezetimibe glucuronide binds specifically to a single site in brush border membranes and to human embryonic kidney 293 cells expressing NPC1L1, which unequivocally establish NPC1 L1 as the direct target of ezETimibe and should facilitate efforts to identify the molecular mechanism of cholesterol transport.

TL;DR: The identification of a new Drosophila class II Smad, Medea, a close homolog of the human tumor-suppressor gene DPC4 is reported, providing a paradigm for, and distinguish between, the requirement for class I and II Smads in Dpp/BMP signaling.

TL;DR: It is determined that PCSK9‐induced up‐regulation of cholesterol biosynthesis genes resulted from intracellular cholesterol starvation, and novel pathways that are presumably regulated by PCSK8 and are independent of its effects on cholesterol uptake are identified.

TL;DR: It is found that hoe-1 is required for hyperproliferation phenotypes seen with mutations in three different genes, suggesting hoe -1 may be generally required for germline proliferation.