Antje Appelt-Menzel

TL;DR: This study systematically investigated the impact of astrocytes, pericytes, and NSCs on hiPSC-derived BBB endothelial cell function and gene expression and confirmed the suitability of the models for drug transport studies.

TL;DR: An automated wounding device, which generates standardized wounds in a sterile atmosphere is developed, and the generation of a three-dimensional full thickness skin equivalent to study wound healing is shown.

TL;DR: iPSC-BECs are exploited as a novel cellular model to study Nm host-pathogen interactions, and the impact of Nm on barrier properties and tight junction complexes is observed, and it is suggested that the paracellular route may contribute to Nm traversal of BECs.

TL;DR: The presented results corroborate earlier reports that poly(2-oxazoline)-based micelles exhibit an extraordinarily high drug loading and are promising candidates for further biomedical applications and underline that the interaction between the polymers and the incorporated small molecules may be more complex and are significantly influenced by both sides, the used carrier and drug, and must be investigated in each specific case.

TL;DR: This study corroborates that in the case of POx and POzi-based polymer micelles, an increased amphiphilic contrast leads to less drug solubilization.