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Antje Krüger
Researcher at Northwestern University
Publications - 19
Citations - 1466
Antje Krüger is an academic researcher from Northwestern University. The author has contributed to research in topics: Glycolysis & Pentose phosphate pathway. The author has an hindex of 11, co-authored 19 publications receiving 1038 citations. Previous affiliations of Antje Krüger include Charité & University of Cambridge.
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Journal ArticleDOI
The return of metabolism: biochemistry and physiology of the pentose phosphate pathway
Anna Stincone,Alessandro Prigione,Thorsten Cramer,Mirjam M.C. Wamelink,Kate Campbell,Eric Cheung,Viridiana Olin-Sandoval,Nana-Maria Grüning,Antje Krüger,Mohammad Tauqeer Alam,Markus A. Keller,Michael Breitenbach,Kevin M. Brindle,Joshua D. Rabinowitz,Markus Ralser,Markus Ralser +15 more
TL;DR: The pentose phosphate pathway (PPP) is a fundamental component of cellular metabolism as discussed by the authors, which shares reactions with the Entner-Doudoroff pathway and the Calvin cycle and divides into an oxidative and non-oxidative branch.
Journal ArticleDOI
The pentose phosphate pathway is a metabolic redox sensor and regulates transcription during the antioxidant response.
Antje Krüger,Nana-Maria Grüning,Mirjam M.C. Wamelink,Martin Kerick,Alexander Kirpy,Dimitri Parkhomchuk,Katharina Bluemlein,Michal-Ruth Schweiger,Aleksey V. Soldatov,Hans Lehrach,Cornelis Jakobs,Markus Ralser +11 more
TL;DR: In this paper, the pentose phosphate pathway (PPP) was found to play a role in the antioxidant response in yeast, and a regulatory signaling function of this metabolic transition in yeast was provided.
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The metabolic background is a global player in Saccharomyces gene expression epistasis.
Mohammad Tauqeer Alam,Aleksej Zelezniak,Aleksej Zelezniak,Michael Mülleder,Pavel V. Shliaha,Roland F. Schwarz,Floriana Capuano,Jakob Vowinckel,Elahe Radmanesfahar,Antje Krüger,Enrica Calvani,Steve Michel,Stefan T. Börno,Stefan Christen,Kiran Raosaheb Patil,Bernd Timmermann,Kathryn S. Lilley,Markus Ralser,Markus Ralser +18 more
TL;DR: Urging a fundamental change of the prevailing laboratory practice of using auxotrophs and nutrient supplemented media, results reveal epistatic intertwining of metabolism with gene expression on the genomic scale and the prevalence of metabolism-dependent epistasis at all regulatory levels.
Journal ArticleDOI
Synthetic biology approaches to biological containment: pre-emptively tackling potential risks
Leticia L. Torres,Antje Krüger,Eszter Csibra,Edoardo Gianni,Vitor B. Pinheiro,Vitor B. Pinheiro +5 more
TL;DR: Recent advances in synthetic biology that contribute to the ongoing efforts to develop new and improved genetic, semantic, metabolic and mechanistic plans for the containment of GEMs are described.
Journal ArticleDOI
ATM is a redox sensor linking genome stability and carbon metabolism.
Antje Krüger,Markus Ralser +1 more
TL;DR: In response to oxidative stress, central carbohydrate metabolism is reconfigured so that the metabolic flux reroutes from glycolysis into the pentose phosphate pathway (PPP), which allows cells to mount an effective response to this cellular stress.