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Antoine Bougoüin
Researcher at University of Paris
Publications - 12
Citations - 1242
Antoine Bougoüin is an academic researcher from University of Paris. The author has contributed to research in topics: Medicine & Tumor microenvironment. The author has an hindex of 4, co-authored 6 publications receiving 488 citations. Previous affiliations of Antoine Bougoüin include French Institute of Health and Medical Research.
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Journal ArticleDOI
B cells are associated with survival and immunotherapy response in sarcoma.
Florent Petitprez,Aurélien de Reyniès,Emily Z. Keung,Tom Wei-Wu Chen,Cheng-Ming Sun,Cheng-Ming Sun,Julien Calderaro,Yung-Ming Jeng,Li Ping Hsiao,Laetitia Lacroix,Laetitia Lacroix,Antoine Bougoüin,Antoine Bougoüin,Marco Moreira,Marco Moreira,Guillaume Lacroix,Guillaume Lacroix,Ivo Natario,Ivo Natario,Julien Adam,Carlo Lucchesi,Yec′han Laizet,Maud Toulmonde,Melissa Amber Burgess,Vanessa Bolejack,Denise K. Reinke,Khalid M. Wani,Wei Lien Wang,Alexander J. Lazar,Christina L. Roland,Jennifer A. Wargo,Antoine Italiano,Catherine Sautès-Fridman,Catherine Sautès-Fridman,Hussein Abdul-Hassan Tawbi,Wolf H. Fridman,Wolf H. Fridman +36 more
TL;DR: Immune profiling of the tumour microenvironment of soft-tissue sarcoma identifies a group of patients with high levels of B-cell infiltration and tertiary lymphoid structures that have improved survival and a high response rate to immune checkpoint blockade therapy.
Journal ArticleDOI
Mature tertiary lymphoid structures predict immune checkpoint inhibitor efficacy in solid tumors independently of PD-L1 expression
Lucile Vanhersecke,Maxime Brunet,Jean-Philippe Guegan,Christophe Rey,Antoine Bougoüin,Sophie Cousin,Sylvestre Le Moulec,Benjamin Besse,Yohann Loriot,Mathieu Larroquette,Isabelle Soubeyran,Maud Toulmonde,Guilhem Roubaud,Simon Pernot,Mathilde Cabart,Francois Chomy,Corentin Lefevre,Kevin Bourcier,Michèle Kind,Ilenia Giglioli,Catherine Sautès-Fridman,Valérie Velasco,Félicie Courgeon,Ezoglin Oflazoglu,Ariel Savina,Aurélien Marabelle,Jean-Charles Soria,Carine Bellera,Casimir Ledoux Sofeu,Alban Bessede,Wolf H. Fridman,François Le Loarer,Antoine Italiano,Antoine Italiano +33 more
TL;DR: It is shown that the presence of mature TLS was associated with improved objective response rate, progression-free survival, and overall survival independently of PD-L1 expression status and CD8+ T-cell density.
Journal ArticleDOI
Pembrolizumab in soft-tissue sarcomas with tertiary lymphoid structures: a phase 2 PEMBROSARC trial cohort
Antoine Italiano,Alban Bessede,Marina Pulido,Emmanuelle Bompas,Sophie Piperno-Neumann,Christine Chevreau,Nicolas Penel,François Bertucci,Maud Toulmonde,Carine Bellera,Jean-Philippe Guégan,Christophe Rey,Catherine Sautès-Fridman,Antoine Bougoüin,Coralie Cantarel,Michèle Kind,Mariella Spalato,Bérengère Dadone-Montaudié,François Le Loarer,Jean-Yves Blay,Wolf H. Fridman +20 more
TL;DR: The results suggest that TLS presence in advanced STS is a potential predictive biomarker to improve patients' selection for pembrolizumab treatment.
Journal ArticleDOI
Early Hepatic Lesions Display Immature Tertiary Lymphoid Structures and Show Elevated Expression of Immune Inhibitory and Immunosuppressive Molecules.
Maxime Meylan,Florent Petitprez,Laetitia Lacroix,Luca Di Tommaso,Massimo Roncalli,Antoine Bougoüin,Alexis Laurent,Giuliana Amaddeo,Daniele Sommacale,Hélène Regnault,Jonathan Derman,Cécile Charpy,Fouad Lafdil,Jean-Michel Pawlotsky,Catherine Sautès-Fridman,Wolf H. Fridman,Julien Calderaro +16 more
TL;DR: Local immune activation occurs in the very early steps of liver carcinogenesis; however, it may not be fully efficient and paradoxically favor immune evasion and progression to full-blown HCC, implications for the development of anti-HCC chemopreventive strategies in cirrhotic patients.
Journal ArticleDOI
Complement C1s and C4d as Prognostic Biomarkers in Renal Cancer: Emergence of Noncanonical Functions of C1s
Marie V. Daugan,Margot Revel,Jules Russick,Marie-Agnès Dragon-Durey,Christine Gaboriaud,Tania Robe-Rybkine,Victoria Poillerat,Anne Grunenwald,Guillaume Lacroix,Antoine Bougoüin,Maxime Meylan,Virginie Verkarre,Stéphane Oudard,A. Mejean,Yann Vano,Geraldine Perkins,Pierre Validire,Xavier Cathelineau,Rafael Sanchez-Salas,Diane Damotte,Véronique Frémeaux-Bacchi,Isabelle Cremer,Catherine Sautès-Fridman,Wolf H. Fridman,Lubka T. Roumenina +24 more
TL;DR: Magrini et al. as discussed by the authors found that C4-activating enzyme C1s was associated with poor prognosis in two cohorts of patients with clear cell renal cell carcinoma (ccRCC).