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Isabelle Cremer
Researcher at University of Paris
Publications - 99
Citations - 8476
Isabelle Cremer is an academic researcher from University of Paris. The author has contributed to research in topics: Immune system & Tumor microenvironment. The author has an hindex of 43, co-authored 90 publications receiving 6793 citations. Previous affiliations of Isabelle Cremer include École Normale Supérieure & Paris Descartes University.
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Consensus guidelines for the detection of immunogenic cell death
Oliver Kepp,Laura Senovilla,Ilio Vitale,Erika Vacchelli,Sandy Adjemian,Patrizia Agostinis,Lionel Apetoh,Fernando Aranda,Vincenzo Barnaba,Norma Bloy,Laura Bracci,Karine Breckpot,David Brough,Aitziber Buqué,Maria G. Castro,Mara Cirone,María Isabel Colombo,Isabelle Cremer,Sandra Demaria,Luciana Dini,Aristides G. Eliopoulos,Alberto Faggioni,Silvia C. Formenti,Jitka Fucikova,Lucia Gabriele,Udo S. Gaipl,Jérôme Galon,Abhishek D. Garg,François Ghiringhelli,Nathalia A. Giese,Zong Sheng Guo,Akseli Hemminki,Martin Herrmann,James W. Hodge,Stefan Holdenrieder,Jamie Honeychurch,Hong-Min Hu,Xing Huang,Timothy M Illidge,Koji Kono,Mladen Korbelik,Dmitri V. Krysko,Sherene Loi,Pedro R. Lowenstein,Enrico Lugli,Yuting Ma,Frank Madeo,Angelo A. Manfredi,Isabelle Martins,Domenico Mavilio,Laurie Menger,Nicolò Merendino,Michael Michaud,Grégoire Mignot,Karen L. Mossman,Gabriele Multhoff,Rudolf Oehler,Fabio Palombo,Theocharis Panaretakis,Jonathan Pol,Enrico Proietti,Jean-Ehrland Ricci,Chiara Riganti,Patrizia Rovere-Querini,Anna Rubartelli,Antonella Sistigu,Mark J. Smyth,Juergen Sonnemann,Radek Spisek,John Stagg,Abdul Qader Sukkurwala,Eric Tartour,Andrew Thorburn,Stephen H. Thorne,Peter Vandenabeele,Francesca Velotti,Samuel T Workenhe,Haining Yang,Wei-Xing Zong,Laurence Zitvogel,Guido Kroemer,Lorenzo Galluzzi +81 more
TL;DR: Strategies conceived to detect surrogate markers of ICD in vitro and to screen large chemical libraries for putative I CD inducers are outlined, based on a high-content, high-throughput platform that was recently developed.
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Presence of B Cells in Tertiary Lymphoid Structures Is Associated with a Protective Immunity in Patients with Lung Cancer
Claire Germain,Sacha Gnjatic,Fella Tamzalit,Samantha Knockaert,Romain Remark,Jeremy Goc,Alice Lepelley,Etienne Becht,Sandrine Katsahian,Geoffray Bizouard,Pierre Validire,Diane Damotte,Marco Alifano,Pierre Magdeleinat,Isabelle Cremer,Jean-Luc Teillaud,Wolf H. Fridman,Catherine Sautès-Fridman,Marie-Caroline Dieu-Nosjean +18 more
TL;DR: B-cell density represents a new prognostic biomarker for NSCLC patient survival, and makes the link between TLS and a protective B cell-mediated immunity.
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Dendritic cells in tumor-associated tertiary lymphoid structures signal a Th1 cytotoxic immune contexture and license the positive prognostic value of infiltrating CD8+ T cells.
Jeremy Goc,Claire Germain,Thi Kim Duy Vo-Bourgais,Audrey Lupo,Christophe Klein,Samantha Knockaert,Luc de Chaisemartin,Hanane Ouakrim,Etienne Becht,Marco Alifano,Pierre Validire,Romain Remark,Scott A. Hammond,Isabelle Cremer,Diane Damotte,Wolf H. Fridman,Catherine Sautès-Fridman,Marie-Caroline Dieu-Nosjean +17 more
TL;DR: These results show how tumors infiltrated by TLS-associated mature DC generate a specific immune contexture characterized by a strong Th1 and cytotoxic orientation that confers the lowest risk of death.
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Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity
Corneliu Henegar,Joan Tordjman,Vincent Achard,Danièle Lacasa,Isabelle Cremer,Isabelle Cremer,Michèle Guerre-Millo,Christine Poitou,Arnaud Basdevant,Vladimir Stich,Nathalie Viguerie,Dominique Langin,Pierre Bedossa,Pierre Bedossa,Jean-Daniel Zucker,Karine Clément +15 more
TL;DR: Tissue and cellular investigations, driven by the analysis of transcriptional interactions, revealed an increased amount of interstitial fibrosis in obese WAT, associated with an infiltration of different types of inflammatory cells, and suggest that phenotypic alterations of human pre-adipocytes, induced by a pro-inflammatory environment, may lead to an excessive synthesis of ECM components.
Journal ArticleDOI
Profound Coordinated Alterations of Intratumoral NK Cell Phenotype and Function in Lung Carcinoma
Sophia Platonova,Julien Cherfils-Vicini,Diane Damotte,Lucile Crozet,Vincent Vieillard,Pierre Validire,Pascale Andre,Marie-Caroline Dieu-Nosjean,Marco Alifano,Jean-François Regnard,Wolf H. Fridman,Catherine Sautès-Fridman,Isabelle Cremer +12 more
TL;DR: The results suggest that the NSCLC tumor microenvironment locally impairs NK cells, rendering them less tumorcidal and thereby supportive to cancer progression.